000000538 001__ 538
000000538 005__ 20260203135031.0
000000538 0247_ $$2DOI$$a10.6083/M4BP00RP
000000538 037__ $$aETD
000000538 245__ $$aAssessment of optical micro-angiography technique to image 3D blood flow within microcirculatory tissue beds in vivo
000000538 269__ $$a2010
000000538 336__ $$aDissertation
000000538 502__ $$bPh.D.
000000538 520__ $$aFunctional microcirculation—intact, RBC‑perfused vessels—is essential for delivering oxygen and nutrients to tissues, and its disruption is a hallmark of many diseases. This work evaluates optical microangiography (OMAG) as a 3D, in vivo imaging tool for quantifying microvascular blood flow in preclinical models where traditional methods lack capillary‑level resolution. OMAG scanning and analysis protocols were optimized across models of cerebral trauma, stroke, meningeal thrombosis, and diabetic peripheral neuropathy to measure perfusion metrics such as blood volume, vessel density, and flow velocity. Results show that OMAG reliably visualizes and quantifies microcirculatory changes, supporting its use as a noninvasive standard for studying vascular pathology.
000000538 540__ $$fCC BY
000000538 542__ $$fIn copyright - single owner
000000538 650__ $$aWounds and Injuries$$028003
000000538 650__ $$aStroke$$032460
000000538 650__ $$aAngiography$$014747
000000538 650__ $$aMicrocirculation$$022263
000000538 650__ $$aCerebrovascular Circulation$$016382
000000538 650__ $$aDiabetic Neuropathies$$017680
000000538 650__ $$aoptical microangiography
000000538 6531_ $$acerebral circulation
000000538 6531_ $$atrauma
000000538 6531_ $$aperipheral blood flow
000000538 691__ $$aSchool of Medicine$$041369
000000538 692__ $$aDepartment of Biomedical Engineering$$041397
000000538 7001_ $$aJia, Yali$$uOregon Health and Science University$$041354
000000538 8564_ $$97b17f3aa-9f25-4b5a-84af-ad67d52fb9fa$$s3477476$$uhttps://digitalcollections.ohsu.edu/record/538/files/539_etd.pdf$$ePublic$$21192088992f68da8aae65d7a837099c3$$31
000000538 905__ $$a/rest/prod/tb/09/j5/67/tb09j567x
000000538 909CO $$ooai:digitalcollections.ohsu.edu:538$$pstudent-work
000000538 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000538 980__ $$aTheses and Dissertations