000000539 001__ 539
000000539 005__ 20260410124448.0
000000539 0247_ $$2DOI$$a10.6083/M46W981T
000000539 037__ $$aETD
000000539 245__ $$aRole of eosinophils and muscarinic receptors in paradoxical airway hyperreactivity associated with antigen challenge
000000539 260__ $$bOregon Health and Science University
000000539 269__ $$a2008
000000539 336__ $$aThesis
000000539 502__ $$bM.S.
000000539 520__ $$aThis work identifies a novel inhibitory role for muscarinic receptors on human and guinea pig eosinophils and demonstrates their functional importance in vivo. Muscarinic signaling reduced eosinophil activation in vitro, while muscarinic blockade during antigen challenge increased eosinophil activation and vagally mediated airway hyperreactivity through mechanisms involving eosinophils and nerve growth factor (NGF). These findings reveal an alternative eosinophil‑dependent pathway for airway hyperreactivity that operates independently of M2 receptor dysfunction and may involve NGF‑driven neural plasticity. The results provide a mechanistic explanation for the limited effectiveness of anticholinergics in chronic asthma and highlight a bidirectional regulatory loop between parasympathetic nerves and eosinophils with clinical implications for asthma therapy.
000000539 540__ $$fCC BY
000000539 542__ $$fIn copyright - single owner
000000539 650__ $$aEosinophils$$018511
000000539 650__ $$aParasympathetic Nervous System$$023593
000000539 650__ $$aBronchial Hyperreactivity$$029199
000000539 650__ $$aCholinergic Antagonists$$031005
000000539 650__ $$aGuinea Pigs$$019785
000000539 650__ $$aHumans$$020376
000000539 650__ $$aReceptors, Muscarinic$$025211
000000539 691__ $$aSchool of Medicine$$041369
000000539 692__ $$aDepartment of Physiology and Pharmacology$$041442
000000539 7001_ $$aVerbout, Norah$$uOregon Health and Science University$$041354
000000539 7201_ $$aFryer, Allison$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000539 8564_ $$9a339ed42-d85f-4fec-a34e-67002cb98877$$s3353828$$uhttps://digitalcollections.ohsu.edu/record/539/files/540_etd.pdf$$ePublic$$2f506aaaac476920aef1203b93e4b96dc$$31
000000539 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000539 905__ $$a/rest/prod/6w/92/4b/82/6w924b82f
000000539 909CO $$ooai:digitalcollections.ohsu.edu:539$$pstudent-work
000000539 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000539 980__ $$aTheses and Dissertations