000000550 001__ 550 000000550 005__ 20260410124448.0 000000550 0247_ $$2DOI$$a10.6083/M4SQ8XDS 000000550 037__ $$aETD 000000550 245__ $$aCharacterization of Rhesus CMV as an in vivo model for cytomegalovirus inhibition of MHC I antigen presentation 000000550 260__ $$bOregon Health and Science University 000000550 269__ $$a2008 000000550 336__ $$aDissertation 000000550 502__ $$bPh.D. 000000550 520__ $$aViruses have co‑evolved with host immune systems, developing sophisticated strategies to evade antiviral defenses. Cytomegaloviruses (CMVs) are highly species‑specific examples of this evolutionary arms race, encoding both conserved and unique immune evasion mechanisms. This dissertation reports the discovery of a novel immunomodulatory protein encoded by Rhesus CMV, termed viral inhibitor of heavy chain expression (VIHCE). VIHCE uniquely inhibits major histocompatibility complex class I antigen presentation by blocking heavy‑chain biosynthesis through targeting signal peptides. In vivo studies further demonstrate that MHC‑I inhibition is essential for Rhesus CMV’s ability to reinfect seropositive hosts, highlighting the importance of immune evasion in CMV persistence and pathogenesis. Provide your feedback on BizChat 000000550 540__ $$fCC BY 000000550 542__ $$fIn copyright - single owner 000000550 650__ $$aMacaca mulatta$$021724 000000550 650__ $$aCytomegalovirus$$017352 000000550 650__ $$aAntigen Presentation$$030374 000000550 650__ $$aMajor Histocompatibility Complex$$021752 000000550 650__ $$aImmune System$$020666 000000550 650__ $$aImmune Evasion$$038852 000000550 650__ $$aCytomegalovirus Infections$$017351 000000550 650__ $$aAllergy and Immunology$$014456 000000550 691__ $$aSchool of Medicine$$041369 000000550 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429 000000550 7001_ $$aPowers, Colin$$uOregon Health and Science University$$041354 000000550 7201_ $$aFrüh, Klaus$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor 000000550 8564_ $$9c95ee5d3-d31b-4895-8ac7-f1ac9474f01e$$s3617940$$uhttps://digitalcollections.ohsu.edu/record/550/files/551_etd.pdf$$ePublic$$23e16ee334be83c1878e457628b90f4dc$$31 000000550 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p> 000000550 905__ $$a/rest/prod/q5/24/jn/79/q524jn79p 000000550 909CO $$ooai:digitalcollections.ohsu.edu:550$$pstudent-work 000000550 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument 000000550 980__ $$aTheses and Dissertations