TY - THES AB - Cervical intraepithelial neoplasia (CIN) diagnostic methods are suboptimal due to limitations in reproducibility and accuracy, which affects clinical management and understanding of risk factors for CIN. These limitations are especially relevant for the histologic diagnosis of moderate dysplasia (CIN 2). We hypothesize that molecular markers, such as p16 and Ki-67, may improve diagnostic reproducibility and accuracy and also lead to a better understanding of cervical cancer epidemiology. AD - Oregon Health and Science University AU - King, Emily DA - 2010 DO - 10.6083/M4NZ85N0 DO - DOI ED - Morgan, Terry ED - Advisor ID - 551 KW - Diagnosis KW - Observer Variation KW - Papillomaviridae KW - Uterine Cervical Dysplasia L1 - https://digitalcollections.ohsu.edu/record/551/files/552_etd.pdf L2 - https://digitalcollections.ohsu.edu/record/551/files/552_etd.pdf L4 - https://digitalcollections.ohsu.edu/record/551/files/552_etd.pdf LK - https://digitalcollections.ohsu.edu/record/551/files/552_etd.pdf N2 - Cervical intraepithelial neoplasia (CIN) diagnostic methods are suboptimal due to limitations in reproducibility and accuracy, which affects clinical management and understanding of risk factors for CIN. These limitations are especially relevant for the histologic diagnosis of moderate dysplasia (CIN 2). We hypothesize that molecular markers, such as p16 and Ki-67, may improve diagnostic reproducibility and accuracy and also lead to a better understanding of cervical cancer epidemiology. PB - Oregon Health and Science University PY - 2010 T1 - Redefining the gold standard for diagnosis and risk factor analysis in cervical dysplasia TI - Redefining the gold standard for diagnosis and risk factor analysis in cervical dysplasia UR - https://digitalcollections.ohsu.edu/record/551/files/552_etd.pdf Y1 - 2010 ER -