000000557 001__ 557
000000557 005__ 20260302103955.0
000000557 0247_ $$2DOI$$a10.6083/M4WH2N0P
000000557 037__ $$aETD
000000557 245__ $$aExcitotoxic mechanisms in the hippocamus and cerebellum during brain ischemia
000000557 260__ $$bOregon Health and Science University
000000557 269__ $$a2009
000000557 336__ $$aDissertation
000000557 502__ $$bPh.D.
000000557 502__ $$gNeuroscience
000000557 520__ $$aBrain ischemia triggers a two‑phase response that ultimately leads to neuronal injury. While much research has focused on the severe ionic disruption of the late phase, early ischemic events may also drive selective neuronal vulnerability. This dissertation investigates early and late ischemic mechanisms in both hippocampal CA1 neurons and cerebellar Purkinje cells. Purkinje cells depolarize to near 0 mV during ischemia, but unlike CA1 neurons, their ischemic depolarization is primarily driven by non‑desensitizing AMPA receptors and is reduced by extracellular calcium removal. Early increases in intracellular calcium in CA1 neurons occur independently of synaptic activity, whereas Purkinje cells do not exhibit the ischemia‑induced rise in miniature EPSCs seen in hippocampus. These regional differences reflect distinct synaptic architectures and reveal that ischemic responses vary substantially across brain areas. This work improves understanding of early ischemic events and highlights important differences in neuronal susceptibility throughout the brain.
000000557 540__ $$fCC BY
000000557 542__ $$fIn copyright - single owner
000000557 650__ $$aGlutamic Acid$$031020
000000557 650__ $$aActins$$014196
000000557 650__ $$aCerebellum$$016353
000000557 650__ $$aCalcium$$015963
000000557 650__ $$aIschemia$$021046
000000557 650__ $$aHippocampus$$020217
000000557 691__ $$aSchool of Medicine$$041369
000000557 692__ $$aVollum Institute$$041509
000000557 7001_ $$aAndrade, Adriana$$uOregon Health and Science University$$041354
000000557 7201_ $$aRossi, David$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000557 8564_ $$97382d785-bac4-4274-9be6-b0fedb872670$$s1322733$$uhttps://digitalcollections.ohsu.edu/record/557/files/558_etd.pdf$$ePublic$$275af046dbb539e95272984c21e681121$$31
000000557 905__ $$a/rest/prod/ns/06/46/00/ns0646000
000000557 909CO $$ooai:digitalcollections.ohsu.edu:557$$pstudent-work
000000557 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000557 980__ $$aTheses and Dissertations