TY  - GEN
AB  - Disrupting memory after retrieval is thought to reflect impairment of reconsolidation, a process that restabilizes memories and can sustain drug cue–controlled behavior. Because drug‑associated stimuli contribute to persistent addiction, pharmacologically targeting reconsolidation is a promising therapeutic strategy. This dissertation investigates the role of the noradrenergic system in reconsolidation of drug memories using the conditioned place preference (CPP) paradigm. Adrenergic receptor antagonists were administered systemically and directly into the basolateral amygdala, a key reconsolidation locus. We evaluated whether blocking noradrenergic signaling at retrieval attenuates subsequent CPP expression, thereby weakening drug cue–memory strength. Findings aim to clarify noradrenergic mechanisms that support reconsolidation and to identify adrenergic targets with potential for pharmacotherapies that reduce the motivational impact of drug‑paired cues.
AD  - Oregon Health and Science University
AU  - Bernardi, Rick
DA  - 2009
DO  - 10.6083/M4N014HG
DO  - DOI
ED  - Berger, S. Paul
ED  - Lattal, K. Matthew
ED  - Mentor
ED  - Mentor
ID  - 559
KW  - Propranolol
KW  - Cocaine
KW  - Amygdala
KW  - Basolateral Nuclear Complex
KW  - Adrenergic Agents
KW  - Adrenergic Antagonists
L1  - https://digitalcollections.ohsu.edu/record/559/files/560_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/559/files/560_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/559/files/560_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/559/files/560_etd.pdf
N2  - Disrupting memory after retrieval is thought to reflect impairment of reconsolidation, a process that restabilizes memories and can sustain drug cue–controlled behavior. Because drug‑associated stimuli contribute to persistent addiction, pharmacologically targeting reconsolidation is a promising therapeutic strategy. This dissertation investigates the role of the noradrenergic system in reconsolidation of drug memories using the conditioned place preference (CPP) paradigm. Adrenergic receptor antagonists were administered systemically and directly into the basolateral amygdala, a key reconsolidation locus. We evaluated whether blocking noradrenergic signaling at retrieval attenuates subsequent CPP expression, thereby weakening drug cue–memory strength. Findings aim to clarify noradrenergic mechanisms that support reconsolidation and to identify adrenergic targets with potential for pharmacotherapies that reduce the motivational impact of drug‑paired cues.
PB  - Oregon Health and Science University
PY  - 2009
T1  - The role of adrenergic receptors in the potential reconsolidation of a cocaine conditioned place preference
TI  - The role of adrenergic receptors in the potential reconsolidation of a cocaine conditioned place preference
UR  - https://digitalcollections.ohsu.edu/record/559/files/560_etd.pdf
Y1  - 2009
ER  -