000000559 001__ 559
000000559 005__ 20260410124448.0
000000559 0247_ $$2DOI$$a10.6083/M4N014HG
000000559 037__ $$aETD
000000559 245__ $$aThe role of adrenergic receptors in the potential reconsolidation of a cocaine conditioned place preference
000000559 260__ $$bOregon Health and Science University
000000559 269__ $$a2009
000000559 336__ $$aDissertation
000000559 502__ $$bPh.D.
000000559 502__ $$gBehavioral & Systems Neuroscience
000000559 520__ $$aDisrupting memory after retrieval is thought to reflect impairment of reconsolidation, a process that restabilizes memories and can sustain drug cue–controlled behavior. Because drug‑associated stimuli contribute to persistent addiction, pharmacologically targeting reconsolidation is a promising therapeutic strategy. This dissertation investigates the role of the noradrenergic system in reconsolidation of drug memories using the conditioned place preference (CPP) paradigm. Adrenergic receptor antagonists were administered systemically and directly into the basolateral amygdala, a key reconsolidation locus. We evaluated whether blocking noradrenergic signaling at retrieval attenuates subsequent CPP expression, thereby weakening drug cue–memory strength. Findings aim to clarify noradrenergic mechanisms that support reconsolidation and to identify adrenergic targets with potential for pharmacotherapies that reduce the motivational impact of drug‑paired cues.
000000559 540__ $$fCC BY
000000559 542__ $$fIn copyright - single owner
000000559 650__ $$aPropranolol$$024694
000000559 650__ $$aCocaine$$016839
000000559 650__ $$aAmygdala$$014642
000000559 650__ $$aBasolateral Nuclear Complex$$040833
000000559 650__ $$aAdrenergic Agents$$030991
000000559 650__ $$aAdrenergic Antagonists$$031000
000000559 691__ $$aSchool of Medicine$$041369
000000559 692__ $$aDepartment of Behavioral Neuroscience$$041394
000000559 7001_ $$aBernardi, Rick$$uOregon Health and Science University$$041354
000000559 7201_ $$aBerger, S. Paul$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000559 7201_ $$aLattal, K. Matthew$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000559 8564_ $$93dba3ec1-f5c1-402a-b3d6-94a589210580$$s756472$$uhttps://digitalcollections.ohsu.edu/record/559/files/560_etd.pdf$$ePublic$$2787d3525d28d885129b39c052a37ecdb$$31
000000559 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000559 905__ $$a/rest/prod/rb/68/xb/84/rb68xb84x
000000559 909CO $$ooai:digitalcollections.ohsu.edu:559$$pstudent-work
000000559 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000559 980__ $$aTheses and Dissertations