000000563 001__ 563
000000563 005__ 20260203151108.0
000000563 0247_ $$2DOI$$a10.6083/M4416V2X
000000563 037__ $$aETD
000000563 245__ $$aCharacterization of rat cytomegalovirus gene expression during persistence
000000563 260__ $$bOregon Health and Science University
000000563 269__ $$a2010
000000563 336__ $$aDissertation
000000563 502__ $$bPh.D.
000000563 520__ $$aCytomegalovirus (CMV) establishes lifelong persistence and latency, yet little is known about viral gene expression during these states in vivo. Using a rat heart transplant model of chronic rejection, where rat CMV (RCMV) accelerates transplant vascular sclerosis, this work characterizes dynamic patterns of viral transcription associated with persistence. Microarray analysis shows that RCMV gene expression is highly restricted and shifts rapidly from replication‑associated genes to those involved in immune evasion. This dissertation identifies 24 RCMV microRNAs with tissue‑specific, stage‑specific expression and characterizes the highly expressed viral gene R116, which is essential for producing infectious virus. These findings advance understanding of CMV gene regulation and mechanisms underlying viral persistence and pathogenesis.
000000563 540__ $$fCC BY
000000563 542__ $$fIn copyright - single owner
000000563 650__ $$aGene Expression$$028717
000000563 650__ $$aCytomegalovirus$$017352
000000563 650__ $$aMicroRNAs$$034671
000000563 650__ $$aGlycoproteins$$019657
000000563 650__ $$aCytomegalovirus Infections$$017351
000000563 6531_ $$acytomegaloviruses
000000563 6531_ $$apersistence
000000563 691__ $$aSchool of Medicine$$041369
000000563 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000563 7001_ $$aMeyer, Christine$$uOregon Health and Science University$$041354
000000563 7201_ $$aStreblow, Daniel$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000563 8564_ $$90548024b-977c-4135-9ea9-06561e73808f$$s2882474$$uhttps://digitalcollections.ohsu.edu/record/563/files/564_etd.pdf$$ePublic$$2313bee9a7d75f9c24cab8c8f0602b94f$$31
000000563 905__ $$a/rest/prod/6d/56/zw/61/6d56zw619
000000563 909CO $$ooai:digitalcollections.ohsu.edu:563$$pstudent-work
000000563 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000563 980__ $$aTheses and Dissertations