000000567 001__ 567
000000567 005__ 20260410124448.0
000000567 0247_ $$2DOI$$a10.6083/M4M043C3
000000567 037__ $$aETD
000000567 245__ $$aDevelopmental regulation of fascin and plastin actin crosslinkers in the chicken basilar papilla
000000567 260__ $$bOregon Health and Science University
000000567 269__ $$a2010
000000567 336__ $$aThesis
000000567 502__ $$bM.S.
000000567 502__ $$gNeuroscience
000000567 520__ $$aActin crosslinkers help shape the structure and mechanics of hair cell stereocilia. We identified several abundant crosslinkers and examined the developmentally regulated expression of fascin‑2 in chicken basilar papilla. Fascin‑2 mRNA and protein levels increased throughout development, especially during stereocilia elongation, and localized to distal stereocilia regions as bundles matured. Other fascin and plastin genes showed varied expression patterns. These results suggest that different crosslinkers support distinct stages of stereocilia growth and contribute to long‑term bundle stability.
000000567 540__ $$fCC BY
000000567 542__ $$fIn copyright - single owner
000000567 650__ $$aCytoskeleton$$017362
000000567 650__ $$aCarrier Proteins$$016184
000000567 650__ $$aStereocilia$$039594
000000567 650__ $$aChickens$$016459
000000567 650__ $$aActins$$014196
000000567 650__ $$aplastin
000000567 650__ $$afascin
000000567 650__ $$aHair Cells, Auditory, Inner$$019811
000000567 691__ $$aSchool of Medicine$$041369
000000567 692__ $$aVollum Institute$$041509
000000567 7001_ $$aSaylor, Katherine$$uOregon Health and Science University$$041354
000000567 7201_ $$aGillespie, Peter$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000567 8564_ $$91dc7b5bc-ad56-426c-9cf4-e904f230e8b8$$s1121444$$uhttps://digitalcollections.ohsu.edu/record/567/files/568_etd.pdf$$ePublic$$23f8800990f5aa582ff076a091f971529$$31
000000567 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000567 905__ $$a/rest/prod/7p/88/cg/56/7p88cg566
000000567 909CO $$ooai:digitalcollections.ohsu.edu:567$$pstudent-work
000000567 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000567 980__ $$aTheses and Dissertations