@article{ETD, recid = {570}, author = {Bartee, Mee}, title = {Characterization of the role of copper transporting ATPase, ATP7B (Wilsons disease protein), in copper homeostasis}, publisher = {Oregon Health and Science University}, school = {Ph.D.}, address = {2008}, number = {ETD}, abstract = {Copper homeostasis is essential for cellular function, requiring precise regulation to meet metabolic needs while preventing toxicity. ATP7B, a P‑type ATPase copper transporter, plays a central role by regulating copper delivery to biosynthetic pathways and controlling intracellular copper levels. Its activity and localization are modulated by tissue‑specific expression, copper‑dependent trafficking, and phosphorylation within a serine‑rich domain. Additional interacting proteins may further influence copper balance. Together, these mechanisms highlight the tightly coordinated regulation required to maintain copper homeostasis in human cells.}, url = {http://digitalcollections.ohsu.edu/record/570}, doi = {https://doi.org/10.6083/M46T0JN3}, }