000000570 001__ 570
000000570 005__ 20260313143652.0
000000570 0247_ $$2DOI$$a10.6083/M46T0JN3
000000570 037__ $$aETD
000000570 245__ $$aCharacterization of the role of copper transporting ATPase, ATP7B (Wilsons disease protein), in copper homeostasis
000000570 260__ $$bOregon Health and Science University
000000570 269__ $$a2008
000000570 336__ $$aDissertation
000000570 502__ $$bPh.D.
000000570 502__ $$gBiochemistry & Molecular Biology (sunsetting)
000000570 520__ $$aCopper homeostasis is essential for cellular function, requiring precise regulation to meet metabolic needs while preventing toxicity. ATP7B, a P‑type ATPase copper transporter, plays a central role by regulating copper delivery to biosynthetic pathways and controlling intracellular copper levels. Its activity and localization are modulated by tissue‑specific expression, copper‑dependent trafficking, and phosphorylation within a serine‑rich domain. Additional interacting proteins may further influence copper balance. Together, these mechanisms highlight the tightly coordinated regulation required to maintain copper homeostasis in human cells.
000000570 540__ $$fCC BY
000000570 542__ $$fIn copyright - single owner
000000570 650__ $$aProtein Transport$$032875
000000570 650__ $$aPhysiology$$024123
000000570 650__ $$aAdenosine Triphosphatases$$014245
000000570 650__ $$aCell Polarity$$029391
000000570 650__ $$aCopper$$017086
000000570 650__ $$aHomeostasis$$020285
000000570 650__ $$aHepatolenticular Degeneration$$020129
000000570 650__ $$aCopper-Transporting ATPases$$012204
000000570 691__ $$aSchool of Medicine$$041369
000000570 692__ $$aDepartment of Biochemistry and Molecular Biology$$041396
000000570 7001_ $$aBartee, Mee$$uOregon Health and Science University$$041354
000000570 7201_ $$aLutsenko, Svetlana$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000570 8564_ $$9c516e22e-4779-473b-b305-f543142bf9ab$$s4965063$$uhttps://digitalcollections.ohsu.edu/record/570/files/571_etd.pdf$$ePublic$$2d2625a2c45a0cfb0f7a8c49c5bc1bc76$$31
000000570 905__ $$a/rest/prod/jm/21/4p/20/jm214p20f
000000570 909CO $$ooai:digitalcollections.ohsu.edu:570$$pstudent-work
000000570 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000570 980__ $$aTheses and Dissertations