TY  - GEN
AB  - Purkinje cells are key regulators of motor coordination, and disruptions in their regular firing patterns contribute to cerebellar ataxias. This thesis examines how altered Purkinje cell pacemaking affects motor control in two mouse models. In a model of episodic ataxia type 1 (EA1), stress‑related β‑adrenergic signaling worsened imprecise firing, while acetazolamide restored precision and blocked stress effects, suggesting a cellular basis for EA1 attacks. In a second model with reduced SK2 channel expression, widespread irregular firing impaired balance only when the remaining normally firing lobules were ablated. These findings highlight the role of precise Purkinje cell output in motor coordination.
AD  - Oregon Health and Science University
AU  - Davis, Forrest
DA  - 2010
DO  - 10.6083/M4Z899DS
DO  - DOI
ED  - Maylie, James
ED  - Adelman, John
ED  - Advisor
ED  - Advisor
ID  - 572
KW  - Purkinje Cells
KW  - Biological Clocks
KW  - Small-Conductance Calcium-Activated Potassium Channels
KW  - Ataxia
KW  - Potassium Channels
KW  - Cerebellum
KW  - Kv1.1 Potassium Channel
L1  - https://digitalcollections.ohsu.edu/record/572/files/573_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/572/files/573_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/572/files/573_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/572/files/573_etd.pdf
N2  - Purkinje cells are key regulators of motor coordination, and disruptions in their regular firing patterns contribute to cerebellar ataxias. This thesis examines how altered Purkinje cell pacemaking affects motor control in two mouse models. In a model of episodic ataxia type 1 (EA1), stress‑related β‑adrenergic signaling worsened imprecise firing, while acetazolamide restored precision and blocked stress effects, suggesting a cellular basis for EA1 attacks. In a second model with reduced SK2 channel expression, widespread irregular firing impaired balance only when the remaining normally firing lobules were ablated. These findings highlight the role of precise Purkinje cell output in motor coordination.
PB  - Oregon Health and Science University
PY  - 2010
T1  - Altered Purkinje cell pacemaking underlies motor deficits in mouse models of cerebellar ataxia
TI  - Altered Purkinje cell pacemaking underlies motor deficits in mouse models of cerebellar ataxia
UR  - https://digitalcollections.ohsu.edu/record/572/files/573_etd.pdf
Y1  - 2010
ER  -