000000572 001__ 572
000000572 005__ 20260203132150.0
000000572 0247_ $$2DOI$$a10.6083/M4Z899DS
000000572 037__ $$aETD
000000572 245__ $$aAltered Purkinje cell pacemaking underlies motor deficits in mouse models of cerebellar ataxia
000000572 260__ $$bOregon Health and Science University
000000572 269__ $$a2010
000000572 336__ $$aDissertation
000000572 502__ $$bPh.D.
000000572 502__ $$gNeuroscience
000000572 520__ $$aPurkinje cells are key regulators of motor coordination, and disruptions in their regular firing patterns contribute to cerebellar ataxias. This thesis examines how altered Purkinje cell pacemaking affects motor control in two mouse models. In a model of episodic ataxia type 1 (EA1), stress‑related β‑adrenergic signaling worsened imprecise firing, while acetazolamide restored precision and blocked stress effects, suggesting a cellular basis for EA1 attacks. In a second model with reduced SK2 channel expression, widespread irregular firing impaired balance only when the remaining normally firing lobules were ablated. These findings highlight the role of precise Purkinje cell output in motor coordination.
000000572 540__ $$fCC BY
000000572 542__ $$fIn copyright - single owner
000000572 650__ $$aPurkinje Cells$$024938
000000572 650__ $$aBiological Clocks$$015560
000000572 650__ $$aSmall-Conductance Calcium-Activated Potassium Channels$$036935
000000572 650__ $$aAtaxia$$015177
000000572 650__ $$aPotassium Channels$$028230
000000572 650__ $$aCerebellum$$016353
000000572 650__ $$aKv1.1 Potassium Channel$$036942
000000572 691__ $$aSchool of Medicine$$041369
000000572 692__ $$aVollum Institute$$041509
000000572 7001_ $$aDavis, Forrest$$uOregon Health and Science University$$041354
000000572 7201_ $$aMaylie, James$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000572 7201_ $$aAdelman, John$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000572 8564_ $$9a8121626-01d4-4f0c-b570-7d54b1d336fb$$s2572947$$uhttps://digitalcollections.ohsu.edu/record/572/files/573_etd.pdf$$ePublic$$23704a8b5b8b5098354a2037692298457$$31
000000572 905__ $$a/rest/prod/k0/69/87/51/k0698751r
000000572 909CO $$ooai:digitalcollections.ohsu.edu:572$$pstudent-work
000000572 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000572 980__ $$aTheses and Dissertations