000000577 001__ 577
000000577 005__ 20260410124449.0
000000577 0247_ $$2DOI$$a10.6083/M49K487F
000000577 037__ $$aETD
000000577 245__ $$aFood insecurity during pregnancy and its relation to birth weight
000000577 260__ $$bOregon Health and Science University
000000577 269__ $$a2008
000000577 336__ $$aThesis
000000577 502__ $$bM.S.
000000577 520__ $$aOverexpression of the c‑Myc transcription factor is common in human breast cancer, yet gene amplification or increased transcription accounts for only a subset of cases. This thesis investigates increased c‑Myc protein stability as an alternative mechanism underlying c‑Myc overexpression. c‑Myc stability was found to be elevated in breast cancer cell lines and primary tumors, associated with increased phosphorylation at serine 62 and decreased phosphorylation at threonine 58. Deregulation of the tumor suppressor Axin1, including altered expression and splice variant usage, was shown to impair c‑Myc degradation and enhance its oncogenic activity. Additionally, activation of the HER2 receptor increased c‑Myc stability and transcriptional activity through pathways regulating serine 62 phosphorylation. Together, these findings identify dysregulated c‑Myc protein stability as a key mechanism in breast cancer and highlight potential targets for Myc‑directed therapies.
000000577 540__ $$fCC BY
000000577 542__ $$fIn copyright - single owner
000000577 650__ $$aPrenatal Nutritional Physiological Phenomena$$034958
000000577 650__ $$aBirth Weight$$015600
000000577 650__ $$aPregnancy$$024523
000000577 650__ $$aPsychology$$024837
000000577 650__ $$aTranscription Factors
000000577 650__ $$aPhosphorylation$$024067
000000577 650__ $$aBreast Neoplasms$$015809
000000577 650__ $$aFood Insecurity$$013447
000000577 691__ $$aSchool of Medicine$$041369
000000577 692__ $$aDepartment of Dietetics and Nutrition$$041408
000000577 7001_ $$aVan Mieghem, Erica$$uOregon Health and Science University$$041354
000000577 7201_ $$aAdams, Elizabeth$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000577 8564_ $$9e73da5c6-25f7-4023-9a83-0219137055cf$$s1339956$$uhttps://digitalcollections.ohsu.edu/record/577/files/578_etd.pdf$$ePublic$$2fe79712886f11bf60a26eb180fc97a8c$$31
000000577 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000577 905__ $$a/rest/prod/r2/07/tp/33/r207tp33p
000000577 909CO $$ooai:digitalcollections.ohsu.edu:577$$pstudent-work
000000577 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000577 980__ $$aTheses and Dissertations