TY  - THES
AB  - Methamphetamine (MA) use among women of child‑bearing age has increased, raising concern about prenatal MA exposure and its long‑term effects on children. Cognitive problems are documented in MA‑exposed children, but the underlying brain mechanisms remain unclear. Human studies are limited due to frequent co‑use of other substances, making rodent models essential. Developmental exposure can be modeled through gestational MA administration or by exposing pups during the first three postnatal weeks, a period similar to the human third trimester. These models help isolate MA’s impact on hippocampal development and later cognitive function.
AD  - Oregon Health and Science University
AU  - Siegel, Jessica
DA  - 2011
DO  - 10.6083/M4DB7ZT0
DO  - DOI
ED  - Raber, Jacob
ED  - Mentor
ID  - 584
KW  - Brain
KW  - Growth and Development
KW  - Adolescent
KW  - Methamphetamine
KW  - Acetylcholine
KW  - Cognition
KW  - Infant, Newborn
KW  - Mice
KW  - Receptors, Cholinergic
L1  - https://digitalcollections.ohsu.edu/record/584/files/585_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/584/files/585_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/584/files/585_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/584/files/585_etd.pdf
N2  - Methamphetamine (MA) use among women of child‑bearing age has increased, raising concern about prenatal MA exposure and its long‑term effects on children. Cognitive problems are documented in MA‑exposed children, but the underlying brain mechanisms remain unclear. Human studies are limited due to frequent co‑use of other substances, making rodent models essential. Developmental exposure can be modeled through gestational MA administration or by exposing pups during the first three postnatal weeks, a period similar to the human third trimester. These models help isolate MA’s impact on hippocampal development and later cognitive function.
PB  - Oregon Health and Science University
PY  - 2011
T1  - The effects of methamphetamine exposure during brain development on the cholinergic system and cognition in mice
TI  - The effects of methamphetamine exposure during brain development on the cholinergic system and cognition in mice
UR  - https://digitalcollections.ohsu.edu/record/584/files/585_etd.pdf
Y1  - 2011
ER  -