000000584 001__ 584
000000584 005__ 20260130122743.0
000000584 0247_ $$2DOI$$a10.6083/M4DB7ZT0
000000584 037__ $$aETD
000000584 245__ $$aThe effects of methamphetamine exposure during brain development on the cholinergic system and cognition in mice
000000584 260__ $$bOregon Health and Science University
000000584 269__ $$a2011
000000584 336__ $$aThesis
000000584 502__ $$bPh.D.
000000584 502__ $$gBehavioral & Systems Neuroscience
000000584 520__ $$aMethamphetamine (MA) use among women of child‑bearing age has increased, raising concern about prenatal MA exposure and its long‑term effects on children. Cognitive problems are documented in MA‑exposed children, but the underlying brain mechanisms remain unclear. Human studies are limited due to frequent co‑use of other substances, making rodent models essential. Developmental exposure can be modeled through gestational MA administration or by exposing pups during the first three postnatal weeks, a period similar to the human third trimester. These models help isolate MA’s impact on hippocampal development and later cognitive function.
000000584 540__ $$fCC BY
000000584 542__ $$fIn copyright - single owner
000000584 650__ $$aBrain$$015788
000000584 650__ $$aGrowth and Development$$036136
000000584 650__ $$aAdolescent$$014285
000000584 650__ $$aMethamphetamine$$022135
000000584 650__ $$aAcetylcholine$$014113
000000584 650__ $$aCognition$$016868
000000584 650__ $$aInfant, Newborn$$020782
000000584 650__ $$aMice$$036842
000000584 650__ $$aReceptors, Cholinergic$$025186
000000584 691__ $$aSchool of Medicine$$041369
000000584 692__ $$aDepartment of Behavioral Neuroscience$$041394
000000584 7001_ $$aSiegel, Jessica$$uOregon Health and Science University$$041354
000000584 7201_ $$aRaber, Jacob$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000584 8564_ $$91f0f0bb3-437a-42e1-becd-3a13895f7393$$s8491704$$uhttps://digitalcollections.ohsu.edu/record/584/files/585_etd.pdf$$ePublic$$25ff62d46226eeb6c710d08eff5e7494b$$31
000000584 905__ $$a/rest/prod/sf/26/85/09/sf268509m
000000584 909CO $$ooai:digitalcollections.ohsu.edu:584$$pstudent-work
000000584 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000584 980__ $$aTheses and Dissertations