@article{ETD,
      recid = {585},
      author = {Holstein, Sarah},
      title = {Contribution of GABA [beta] receptors to acute ethanol  sensitivity and as a pharmacotherapeutic target},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2008},
      number = {ETD},
      abstract = {Increased sensitivity to the behavioral stimulant effects  of ethanol may be a risk factor for alcohol use disorder  and treatments that reduce the stimulant response may be  potential pharmacotherapies in examining the neurochemical  substrates underlying the stimulant response to ethanol and  mice selectively bred for extreme sensitivity (FAST)  and  insensitivity (SLOW) to this response The Y-aminobutyric  acid GABA system has repeatedly been implicated these lines  differed in sensitivity to a wide array of GABA a receptor  modulators and to the GABA B receptor agonist Baclofen and  Baclofen and attenuated the stimulant response to ethanol  in fast mice. Therefore GABA systems are likely a critical  component involved in the stimulant response to ethanol  however the exact contribution of this system is not known  the main purpose of this dissertation was to examine how  selective breeding of the fast and slow lines had altered  GABA systems and GABA B receptors in particular as well as  to examine potential mechanisms by which GABAergic drugs  attenuate the stimulant response to ethanol},
      url = {http://digitalcollections.ohsu.edu/record/585},
      doi = {https://doi.org/10.6083/M48K772M},
}