TY  - THES
AB  - Increased sensitivity to the behavioral stimulant effects of ethanol may be a risk factor for alcohol use disorder and treatments that reduce the stimulant response may be potential pharmacotherapies in examining the neurochemical substrates underlying the stimulant response to ethanol and mice selectively bred for extreme sensitivity (FAST)  and insensitivity (SLOW) to this response The Y-aminobutyric acid GABA system has repeatedly been implicated these lines differed in sensitivity to a wide array of GABA a receptor modulators and to the GABA B receptor agonist Baclofen and Baclofen and attenuated the stimulant response to ethanol in fast mice. Therefore GABA systems are likely a critical component involved in the stimulant response to ethanol however the exact contribution of this system is not known the main purpose of this dissertation was to examine how selective breeding of the fast and slow lines had altered GABA systems and GABA B receptors in particular as well as to examine potential mechanisms by which GABAergic drugs attenuate the stimulant response to ethanol
AD  - Oregon Health and Science University
AU  - Holstein, Sarah
DA  - 2008
DO  - 10.6083/M48K772M
DO  - DOI
ED  - Phillips, Tamara
ED  - Mentor
ID  - 585
KW  - Alcoholism
KW  - Dopamine
KW  - Ataxia
KW  - gamma-Aminobutyric Acid
KW  - Drug Therapy
KW  - Risk Factors
KW  - Ethanol
KW  - Mice
KW  - Selective Breeding
KW  - Receptors, GABA-B
KW  - Receptors, GABA-A
KW  - GABA-B Receptor Agonists
L1  - https://digitalcollections.ohsu.edu/record/585/files/586_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/585/files/586_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/585/files/586_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/585/files/586_etd.pdf
N2  - Increased sensitivity to the behavioral stimulant effects of ethanol may be a risk factor for alcohol use disorder and treatments that reduce the stimulant response may be potential pharmacotherapies in examining the neurochemical substrates underlying the stimulant response to ethanol and mice selectively bred for extreme sensitivity (FAST)  and insensitivity (SLOW) to this response The Y-aminobutyric acid GABA system has repeatedly been implicated these lines differed in sensitivity to a wide array of GABA a receptor modulators and to the GABA B receptor agonist Baclofen and Baclofen and attenuated the stimulant response to ethanol in fast mice. Therefore GABA systems are likely a critical component involved in the stimulant response to ethanol however the exact contribution of this system is not known the main purpose of this dissertation was to examine how selective breeding of the fast and slow lines had altered GABA systems and GABA B receptors in particular as well as to examine potential mechanisms by which GABAergic drugs attenuate the stimulant response to ethanol
PB  - Oregon Health and Science University
PY  - 2008
T1  - Contribution of GABA [beta] receptors to acute ethanol sensitivity and as a pharmacotherapeutic target
TI  - Contribution of GABA [beta] receptors to acute ethanol sensitivity and as a pharmacotherapeutic target
UR  - https://digitalcollections.ohsu.edu/record/585/files/586_etd.pdf
Y1  - 2008
ER  -