000000585 001__ 585 000000585 005__ 20260410124449.0 000000585 0247_ $$2DOI$$a10.6083/M48K772M 000000585 037__ $$aETD 000000585 245__ $$aContribution of GABA [beta] receptors to acute ethanol sensitivity and as a pharmacotherapeutic target 000000585 260__ $$bOregon Health and Science University 000000585 269__ $$a2008 000000585 336__ $$aThesis 000000585 502__ $$bPh.D. 000000585 502__ $$gBehavioral & Systems Neuroscience 000000585 520__ $$aIncreased sensitivity to the behavioral stimulant effects of ethanol may be a risk factor for alcohol use disorder and treatments that reduce the stimulant response may be potential pharmacotherapies in examining the neurochemical substrates underlying the stimulant response to ethanol and mice selectively bred for extreme sensitivity (FAST) and insensitivity (SLOW) to this response The Y-aminobutyric acid GABA system has repeatedly been implicated these lines differed in sensitivity to a wide array of GABA a receptor modulators and to the GABA B receptor agonist Baclofen and Baclofen and attenuated the stimulant response to ethanol in fast mice. Therefore GABA systems are likely a critical component involved in the stimulant response to ethanol however the exact contribution of this system is not known the main purpose of this dissertation was to examine how selective breeding of the fast and slow lines had altered GABA systems and GABA B receptors in particular as well as to examine potential mechanisms by which GABAergic drugs attenuate the stimulant response to ethanol 000000585 540__ $$fCC BY 000000585 542__ $$fIn copyright - single owner 000000585 650__ $$aAlcoholism$$014412 000000585 650__ $$aDopamine$$018026 000000585 650__ $$aAtaxia$$015177 000000585 650__ $$agamma-Aminobutyric Acid$$019337 000000585 650__ $$aDrug Therapy$$018086 000000585 650__ $$aRisk Factors$$025522 000000585 650__ $$aEthanol$$014406 000000585 650__ $$aMice$$036842 000000585 650__ $$aSelective Breeding$$011277 000000585 650__ $$aReceptors, GABA-B$$030488 000000585 650__ $$aReceptors, GABA-A$$025198 000000585 650__ $$aGABA-B Receptor Agonists$$039350 000000585 691__ $$aSchool of Medicine$$041369 000000585 692__ $$aDepartment of Behavioral Neuroscience$$041394 000000585 7001_ $$aHolstein, Sarah$$uOregon Health and Science University$$041354 000000585 7201_ $$aPhillips, Tamara$$uOregon Health and Science University$$041354$$7Personal$$eMentor 000000585 8564_ $$928e1ea41-bc63-42b3-b2f2-f37624d49b51$$s11064324$$uhttps://digitalcollections.ohsu.edu/record/585/files/586_etd.pdf$$ePublic$$245a07849bb75ebca58c2cdd75b88be44$$31 000000585 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p> 000000585 905__ $$a/rest/prod/ww/72/bb/52/ww72bb527 000000585 909CO $$ooai:digitalcollections.ohsu.edu:585$$pstudent-work 000000585 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument 000000585 980__ $$aTheses and Dissertations