000000587 001__ 587
000000587 005__ 20250310135215.0
000000587 0247_ $$2DOI$$a10.6083/M4125QMG
000000587 037__ $$aETD
000000587 245__ $$aIntegrating genetics and protemics to study alcohol-drinking behavior
000000587 260__ $$bOregon Health and Science University
000000587 269__ $$a2011
000000587 336__ $$aDissertation
000000587 502__ $$bPh.D.
000000587 520__ $$aThe Portland Alcohol Research Center (PARC) was established to investigate the genetic basis of alcohol dependence.  One line of inquiry utilizes mouse strains that are widely divergent in alcohol‐related behaviors.  Decades of genetics research comparing mouse strains has identified many regions of the genome associated with such quantitative traits.  These regions are called Quantitative Trait Loci (QTLs).  Microarrays have been used to identify which genes within the QTLs are differentially expressed and are therefore potentially causal; however, genetic variants that affect probe hybridization lead to many false conclusions.  Here, we used quantitative proteomics to compare brain striata between two mouse strains for which abundant QTL and transcriptomic data is available.  The primary aims of this research were to (1) identify differentially expressed proteins that lie within QTLs and are therefore candidate causal proteins, (2) determine if genetic variants also lead to spurious results in quantitative proteomics, and (3) compare transcriptomic and proteomic datasets to determine their agreement.
000000587 540__ $$fCC BY
000000587 542__ $$fIn copyright - single owner
000000587 650__ $$aQuantitative Trait Loci$$035050
000000587 650__ $$aAlcohol Drinking$$014403
000000587 650__ $$aGenomics$$033016
000000587 650__ $$aProteomics$$035059
000000587 650__ $$aGenetics$$019472
000000587 650__ $$aAmino Acid Substitution$$032012
000000587 650__ $$aEthanol$$014406
000000587 650__ $$aQuantitative Trait Loci$$035050
000000587 650__ $$aAlcoholism$$014412
000000587 651__ $$aOregon--Portland$$041692
000000587 6531_ $$aqtl genes
000000587 691__ $$aSchool of Medicine$$041369
000000587 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000000587 7001_ $$aFei, Suzanne$$uOregon Health and Science University$$041354
000000587 7201_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000587 7201_ $$aDavid, Larry$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000587 7201_ $$aBoudreau, Eilis$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000587 8564_ $$9913b76d7-c310-4879-84c0-2140b4ac1086$$s1815642$$uhttps://digitalcollections.ohsu.edu/record/587/files/588_etd.pdf
000000587 905__ $$a/rest/prod/70/79/57/68/707957685
000000587 909CO $$ooai:digitalcollections.ohsu.edu:587$$pstudent-work
000000587 980__ $$aBiomedical Informatics