TY  - THES
AB  - Colorectal cancer is the third most common cancer and second leading cause of cancer-related death in the U.S. Colonoscopic screening can reduce mortality but carries risks of complications. This study analyzed 21,302 patients undergoing screening or surveillance colonoscopy to identify predictors of serious complications and clinically significant neoplasia (>9 mm). Multivariate logistic regression assessed risk factors and estimated the number needed to endoscope (NNE) for each outcome. Serious complications occurred in 0.31% of patients, while 8.76% had large neoplasia. Anticoagulation therapy significantly increased complication risk without improving yield. Predictors of neoplasia included male sex, older age, ASA class ≥II, and prior positive screening. Aspirin/NSAID use appeared protective. Findings suggest screening benefits may diminish at older ages as complication risk rises, and anticoagulation markedly elevates risk without added benefit.
AD  - Oregon Health and Science University
AU  - Williams, J. Lucas
DA  - 2011
DO  - 10.6083/M42V2D34
DO  - DOI
ED  - Lieberman, David
ED  - Peters, Dawn
ED  - Morris, Cynthia
ED  - Advisor
ED  - Advisor
ED  - Mentor
ID  - 602
KW  - Intraoperative Complications
KW  - Colonoscopy
KW  - Rectum
KW  - Postoperative Complications
KW  - Colorectal Neoplasms
KW  - Male
KW  - Risk Factors
KW  - Anti-Inflammatory Agents, Non-Steroidal
KW  - Anticoagulants
KW  - Colon
KW  - surgery
KW  - cancer
L1  - https://digitalcollections.ohsu.edu/record/602/files/603_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/602/files/603_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/602/files/603_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/602/files/603_etd.pdf
N2  - Colorectal cancer is the third most common cancer and second leading cause of cancer-related death in the U.S. Colonoscopic screening can reduce mortality but carries risks of complications. This study analyzed 21,302 patients undergoing screening or surveillance colonoscopy to identify predictors of serious complications and clinically significant neoplasia (>9 mm). Multivariate logistic regression assessed risk factors and estimated the number needed to endoscope (NNE) for each outcome. Serious complications occurred in 0.31% of patients, while 8.76% had large neoplasia. Anticoagulation therapy significantly increased complication risk without improving yield. Predictors of neoplasia included male sex, older age, ASA class ≥II, and prior positive screening. Aspirin/NSAID use appeared protective. Findings suggest screening benefits may diminish at older ages as complication risk rises, and anticoagulation markedly elevates risk without added benefit.
PB  - Oregon Health and Science University
PY  - 2011
T1  - Estimates of complications and clinically significant findings in screening and surveillance colonoscopy
TI  - Estimates of complications and clinically significant findings in screening and surveillance colonoscopy
UR  - https://digitalcollections.ohsu.edu/record/602/files/603_etd.pdf
Y1  - 2011
ER  -