000000602 001__ 602
000000602 005__ 20260120144836.0
000000602 0247_ $$2DOI$$a10.6083/M42V2D34
000000602 037__ $$aETD
000000602 245__ $$aEstimates of complications and clinically significant findings in screening and surveillance colonoscopy
000000602 260__ $$bOregon Health and Science University
000000602 269__ $$a2011
000000602 336__ $$aThesis
000000602 502__ $$bM.P.H.
000000602 520__ $$aColorectal cancer is the third most common cancer and second leading cause of cancer-related death in the U.S. Colonoscopic screening can reduce mortality but carries risks of complications. This study analyzed 21,302 patients undergoing screening or surveillance colonoscopy to identify predictors of serious complications and clinically significant neoplasia (>9 mm). Multivariate logistic regression assessed risk factors and estimated the number needed to endoscope (NNE) for each outcome. Serious complications occurred in 0.31% of patients, while 8.76% had large neoplasia. Anticoagulation therapy significantly increased complication risk without improving yield. Predictors of neoplasia included male sex, older age, ASA class ≥II, and prior positive screening. Aspirin/NSAID use appeared protective. Findings suggest screening benefits may diminish at older ages as complication risk rises, and anticoagulation markedly elevates risk without added benefit.
000000602 540__ $$fCC BY
000000602 542__ $$fIn copyright - single owner
000000602 650__ $$aIntraoperative Complications$$020972
000000602 650__ $$aColonoscopy$$016908
000000602 650__ $$aRectum$$025241
000000602 650__ $$aPostoperative Complications$$024462
000000602 650__ $$aColorectal Neoplasms$$028197
000000602 650__ $$aMale$$021762
000000602 650__ $$aRisk Factors$$025522
000000602 650__ $$aAnti-Inflammatory Agents, Non-Steroidal$$014842
000000602 650__ $$aAnticoagulants$$014868
000000602 650__ $$aColon$$016901
000000602 6531_ $$asurgery
000000602 6531_ $$acancer
000000602 691__ $$aSchool of Medicine$$041369
000000602 692__ $$aDepartment of Public Health and Preventive Medicine$$041444
000000602 7001_ $$aWilliams, J. Lucas$$uOregon Health and Science University$$041354
000000602 7201_ $$aLieberman, David$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000602 7201_ $$aPeters, Dawn$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000602 7201_ $$aMorris, Cynthia$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000602 8564_ $$989f15aa5-6178-4203-8fb4-7e0e6481521c$$s480067$$uhttps://digitalcollections.ohsu.edu/record/602/files/603_etd.pdf$$ePublic$$24c8b7d699d0f63595cb14dc9cde3f8b1$$31
000000602 905__ $$a/rest/prod/00/00/00/03/00000003t
000000602 909CO $$ooai:digitalcollections.ohsu.edu:602$$pstudent-work
000000602 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000602 980__ $$aTheses and Dissertations