@article{ETD,
      recid = {604},
      author = {Stoffregen, Eric},
      title = {Genetic analysis of chromosome replication timing: an  autosomal locus that controls chromosome-wide replication  timing and mono-allelic expression},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2011},
      number = {ETD},
      abstract = {A subset of tumor-derived chromosomal rearrangements  exhibits delayed replication timing (DRT) and delayed  mitotic chromosome condensation (DMC), leading to genomic  instability and a markedly increased rate of new  chromosomal rearrangements. Using site-specific  recombination-mediated chromosome engineering, we  identified a cis-acting locus on human chromosome 6 that  regulates replication timing across the entire chromosome.  Disruption of this locus induces chromosome-wide  replication delay and reactivates previously silent alleles  of mono-allelically expressed genes. This region contains a  large intergenic non-coding RNA, named ASAR6 (asynchronous  replication and autosomal RNA on chromosome 6), which  replicates asynchronously in coordination with other  mono-allelically expressed genes. These findings reveal  that human autosomes harbor discrete loci controlling  replication timing, mono-allelic expression, and chromosome  stability. Alterations in such loci may contribute to  genomic instability observed in cancer and following  ionizing radiation exposure.},
      url = {http://digitalcollections.ohsu.edu/record/604},
      doi = {https://doi.org/10.6083/M4TD9V96},
}