000000607 001__ 607
000000607 005__ 20260113084547.0
000000607 0247_ $$2DOI$$a10.6083/M4F47M3P
000000607 037__ $$aETD
000000607 245__ $$aMultiple sclerosis: how cognitive performance relates to quality of life, depression, and perception of deficits
000000607 260__ $$bOregon Health and Science University
000000607 269__ $$a2011
000000607 336__ $$aThesis
000000607 502__ $$bM.P.H.
000000607 520__ $$aCognitive impairment in multiple sclerosis (MS) significantly impacts quality of life, yet its relationship to depression and self-reported deficits remains unclear. In 298 MS patients across three clinical trials, objective cognitive impairment correlated with lower mental quality of life but not with mild or moderate depression. Self-reported deficits strongly reflected depressive symptoms rather than actual cognitive decline, while caregiver reports aligned more closely with objective impairment but were influenced by physical disability and depression. These findings underscore the need for routine objective cognitive screening and careful evaluation of depression when addressing cognitive complaints in MS.
000000607 540__ $$fCC BY
000000607 542__ $$fIn copyright - single owner
000000607 650__ $$aMultiple Sclerosis$$022506
000000607 650__ $$aQuality of Life$$025032
000000607 650__ $$aCognition Disorders$$016869
000000607 650__ $$aDepression$$017614
000000607 650__ $$aSelf Report$$038946
000000607 650__ $$aCognition$$016868
000000607 650__ $$aCognitive Dysfunction$$039814
000000607 650__ $$aConditioning, Psychological$$017003
000000607 691__ $$aSchool of Medicine$$041369
000000607 692__ $$aDepartment of Public Health and Preventive Medicine$$041444
000000607 7001_ $$aAllen, Rebecca$$uOregon Health and Science University$$041354
000000607 8564_ $$90fca2951-423e-4346-a842-a10a225d0824$$s715819$$uhttps://digitalcollections.ohsu.edu/record/607/files/608_etd.pdf$$ePublic$$2c28dcf6e9f51cced8831cc8324d2d41c$$31
000000607 905__ $$a/rest/prod/vm/40/xr/58/vm40xr584
000000607 909CO $$ooai:digitalcollections.ohsu.edu:607$$pstudent-work
000000607 980__ $$aTheses and Dissertations