@article{ETD,
      recid = {625},
      author = {McKenna, Kathryn},
      title = {Development and characterization of extracellular matrix  based vascular graft biomaterials},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2011},
      number = {ETD},
      abstract = {Small-diameter vascular grafts remain a critical unmet  need due to limitations of autologous vessels and synthetic  grafts. This work investigates the role of extracellular  matrix (ECM) in vascular function and develops novel  biomaterials, including electrospun human recombinant  tropoelastin grafts and ECM-modified ePTFE grafts. These  materials demonstrated favorable mechanical properties and  vascular cell compatibility. A biaxial constitutive model  was introduced for standardized evaluation of graft  mechanics. Endothelial outgrowth cell responses to ECM  proteins were assessed for thrombogenic and inflammatory  potential. Findings provide new insights into ECM–cell  interactions and advance strategies for clinically viable  small-diameter vascular grafts.},
      url = {http://digitalcollections.ohsu.edu/record/625},
      doi = {https://doi.org/10.6083/M43R0QV7},
}