TY  - GEN
AB  - Small-diameter vascular grafts remain a critical unmet need due to limitations of autologous vessels and synthetic grafts. This work investigates the role of extracellular matrix (ECM) in vascular function and develops novel biomaterials, including electrospun human recombinant tropoelastin grafts and ECM-modified ePTFE grafts. These materials demonstrated favorable mechanical properties and vascular cell compatibility. A biaxial constitutive model was introduced for standardized evaluation of graft mechanics. Endothelial outgrowth cell responses to ECM proteins were assessed for thrombogenic and inflammatory potential. Findings provide new insights into ECM–cell interactions and advance strategies for clinically viable small-diameter vascular grafts.
AD  - Oregon Health and Science University
AU  - McKenna, Kathryn
DA  - 2011
DO  - 10.6083/M43R0QV7
DO  - DOI
ED  - Hinds, Monica
ED  - Advisor
ID  - 625
KW  - Thrombosis
KW  - Blood Vessel Prosthesis
KW  - Tissue Engineering
KW  - Tropoelastin
KW  - Extracellular Matrix
KW  - Vascular Grafting
KW  - electrospinning
L1  - https://digitalcollections.ohsu.edu/record/625/files/626_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/625/files/626_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/625/files/626_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/625/files/626_etd.pdf
N2  - Small-diameter vascular grafts remain a critical unmet need due to limitations of autologous vessels and synthetic grafts. This work investigates the role of extracellular matrix (ECM) in vascular function and develops novel biomaterials, including electrospun human recombinant tropoelastin grafts and ECM-modified ePTFE grafts. These materials demonstrated favorable mechanical properties and vascular cell compatibility. A biaxial constitutive model was introduced for standardized evaluation of graft mechanics. Endothelial outgrowth cell responses to ECM proteins were assessed for thrombogenic and inflammatory potential. Findings provide new insights into ECM–cell interactions and advance strategies for clinically viable small-diameter vascular grafts.
PB  - Oregon Health and Science University
PY  - 2011
T1  - Development and characterization of extracellular matrix based vascular graft biomaterials
TI  - Development and characterization of extracellular matrix based vascular graft biomaterials
UR  - https://digitalcollections.ohsu.edu/record/625/files/626_etd.pdf
Y1  - 2011
ER  -