000000625 001__ 625
000000625 005__ 20260120144836.0
000000625 0247_ $$2DOI$$a10.6083/M43R0QV7
000000625 037__ $$aETD
000000625 245__ $$aDevelopment and characterization of extracellular matrix based vascular graft biomaterials
000000625 260__ $$bOregon Health and Science University
000000625 269__ $$a2011
000000625 336__ $$aDissertation
000000625 502__ $$bPh.D.
000000625 520__ $$aSmall-diameter vascular grafts remain a critical unmet need due to limitations of autologous vessels and synthetic grafts. This work investigates the role of extracellular matrix (ECM) in vascular function and develops novel biomaterials, including electrospun human recombinant tropoelastin grafts and ECM-modified ePTFE grafts. These materials demonstrated favorable mechanical properties and vascular cell compatibility. A biaxial constitutive model was introduced for standardized evaluation of graft mechanics. Endothelial outgrowth cell responses to ECM proteins were assessed for thrombogenic and inflammatory potential. Findings provide new insights into ECM–cell interactions and advance strategies for clinically viable small-diameter vascular grafts.
000000625 540__ $$fCC BY
000000625 542__ $$fIn copyright - single owner
000000625 650__ $$aThrombosis$$027034
000000625 650__ $$aBlood Vessel Prosthesis$$015682
000000625 650__ $$aTissue Engineering$$033051
000000625 650__ $$aTropoelastin$$027428
000000625 650__ $$aExtracellular Matrix$$018796
000000625 650__ $$aVascular Grafting$$039073
000000625 6531_ $$aelectrospinning
000000625 691__ $$aSchool of Medicine$$041369
000000625 692__ $$aDepartment of Biomedical Engineering$$041397
000000625 7001_ $$aMcKenna, Kathryn$$uOregon Health and Science University$$041354
000000625 7201_ $$aHinds, Monica$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000625 8564_ $$9868a92be-8a81-4b01-8371-5cb06769c8b4$$s8859194$$uhttps://digitalcollections.ohsu.edu/record/625/files/626_etd.pdf$$ePublic$$2dd93e95e659c482b9665ce415bba9cc6$$31
000000625 905__ $$a/rest/prod/ww/72/bb/53/ww72bb53h
000000625 909CO $$ooai:digitalcollections.ohsu.edu:625$$pstudent-work
000000625 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000625 980__ $$aTheses and Dissertations