000000631 001__ 631
000000631 005__ 20250424232536.0
000000631 0247_ $$2DOI$$a10.6083/M4B8564V
000000631 037__ $$aETD
000000631 245__ $$aIdentification of candidate genes involved in atherosclerotic cardovascular disease: a systems biology appproach
000000631 260__ $$bOregon Health and Science University
000000631 269__ $$a2010
000000631 336__ $$aThesis
000000631 502__ $$bM.S.
000000631 520__ $$aGene expression profiles and mass-spectrometry analysis of a plaque have revealed genes and proteins involved in atherosclerotic plaque progression. Though differentially expressed genes in an atherosclerotic plaque progression have been identified previously this is the first study that has combined gene expression data with proteins identified from different stages of plaque progression to identify pathways and candidate genes affecting the state of a plaque using a network approach. We constructed an unstable plaque network with 59 genes of which 9 were transcription factors 10 genes were over expressed and 12 genes were under-expressed Of all genes and proteins found to be associated with a plaque progression we further identified and prioritized candidate genes which could be potential biomarker or drug targets to prevent progression of a plaque. In this study, we also show that just differential expression of genes does not identify genes that are associated with the disease state but not differentially expressed.
000000631 540__ $$fCC BY
000000631 542__ $$fIn copyright - single owner
000000631 650__ $$aSystems Biology$$036214
000000631 650__ $$aAtherosclerosis$$036329
000000631 650__ $$aGene Expression Profiling$$032769
000000631 650__ $$aTranscriptome$$039582
000000631 650__ $$aBiomarkers$$028395
000000631 650__ $$aPlaque, Atherosclerotic$$039118
000000631 6531_ $$aplaque
000000631 691__ $$aSchool of Medicine$$041369
000000631 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000000631 7001_ $$aAnur, Pavana$$uOregon Health and Science University$$041354
000000631 7201_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000631 8564_ $$993d37a37-d3fc-4b10-adc4-4428183bfbb7$$s726844$$uhttps://digitalcollections.ohsu.edu/record/631/files/632_etd.pdf$$ePublic$$2d7dd43d8e7e353857d39265c4b03473b$$31
000000631 905__ $$a/rest/prod/w6/63/43/62/w6634362n
000000631 909CO $$ooai:digitalcollections.ohsu.edu:631$$pstudent-work
000000631 980__ $$aBiomedical Informatics