@article{ETD,
      recid = {639},
      author = {Curtis, Damian},
      title = {Biochemical functions of C-terminal binding proteins:  their role in short-range repression and dimerization},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2011},
      number = {ETD},
      abstract = {Carboxyl-terminal Binding Proteins (CtBP1 and CtBP2) are  transcriptional co-repressors originally identified through  interactions with adenoviral E1A, implicating them in cell  cycle regulation and oncogenesis. CtBPs mediate repression  of genes controlling proliferation, apoptosis, adhesion,  and invasiveness via PxDLS motif-dependent binding. Despite  structural similarity to 2-hydroxyacid dehydrogenases,  CtBPs exhibit unique nuclear and cytoplasmic roles,  including Golgi fission and synaptic ribbon formation.  While isoforms share overlapping expression and  co-repressor complex membership, knockout studies reveal  distinct developmental functions. This work explores CtBP  biology, emphasizing their dual roles, protein  interactions, and implications for transcriptional  regulation and tumorigenesis.},
      url = {http://digitalcollections.ohsu.edu/record/639},
      doi = {https://doi.org/10.6083/M498851X},
}