TY  - GEN
AB  - Carboxyl-terminal Binding Proteins (CtBP1 and CtBP2) are transcriptional co-repressors originally identified through interactions with adenoviral E1A, implicating them in cell cycle regulation and oncogenesis. CtBPs mediate repression of genes controlling proliferation, apoptosis, adhesion, and invasiveness via PxDLS motif-dependent binding. Despite structural similarity to 2-hydroxyacid dehydrogenases, CtBPs exhibit unique nuclear and cytoplasmic roles, including Golgi fission and synaptic ribbon formation. While isoforms share overlapping expression and co-repressor complex membership, knockout studies reveal distinct developmental functions. This work explores CtBP biology, emphasizing their dual roles, protein interactions, and implications for transcriptional regulation and tumorigenesis.
AD  - Oregon Health and Science University
AU  - Curtis, Damian
DA  - 2011
DO  - 10.6083/M498851X
DO  - DOI
ED  - Lundblad, James
ED  - Mentor
ID  - 639
KW  - Dimerization
KW  - Embryonic Development
KW  - Embryology
KW  - DNA-Binding Proteins
KW  - Carcinogenesis
KW  - Co-Repressor Proteins
L1  - https://digitalcollections.ohsu.edu/record/639/files/640_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/639/files/640_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/639/files/640_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/639/files/640_etd.pdf
N2  - Carboxyl-terminal Binding Proteins (CtBP1 and CtBP2) are transcriptional co-repressors originally identified through interactions with adenoviral E1A, implicating them in cell cycle regulation and oncogenesis. CtBPs mediate repression of genes controlling proliferation, apoptosis, adhesion, and invasiveness via PxDLS motif-dependent binding. Despite structural similarity to 2-hydroxyacid dehydrogenases, CtBPs exhibit unique nuclear and cytoplasmic roles, including Golgi fission and synaptic ribbon formation. While isoforms share overlapping expression and co-repressor complex membership, knockout studies reveal distinct developmental functions. This work explores CtBP biology, emphasizing their dual roles, protein interactions, and implications for transcriptional regulation and tumorigenesis.
PB  - Oregon Health and Science University
PY  - 2011
T1  - Biochemical functions of C-terminal binding proteins: their role in short-range repression and dimerization
TI  - Biochemical functions of C-terminal binding proteins: their role in short-range repression and dimerization
UR  - https://digitalcollections.ohsu.edu/record/639/files/640_etd.pdf
Y1  - 2011
ER  -