000000639 001__ 639
000000639 005__ 20260107124338.0
000000639 0247_ $$2DOI$$a10.6083/M498851X
000000639 037__ $$aETD
000000639 245__ $$aBiochemical functions of C-terminal binding proteins: their role in short-range repression and dimerization
000000639 260__ $$bOregon Health and Science University
000000639 269__ $$a2011
000000639 336__ $$aDissertation
000000639 502__ $$bPh.D.
000000639 502__ $$gBiochemistry & Molecular Biology (sunsetting)
000000639 520__ $$aCarboxyl-terminal Binding Proteins (CtBP1 and CtBP2) are transcriptional co-repressors originally identified through interactions with adenoviral E1A, implicating them in cell cycle regulation and oncogenesis. CtBPs mediate repression of genes controlling proliferation, apoptosis, adhesion, and invasiveness via PxDLS motif-dependent binding. Despite structural similarity to 2-hydroxyacid dehydrogenases, CtBPs exhibit unique nuclear and cytoplasmic roles, including Golgi fission and synaptic ribbon formation. While isoforms share overlapping expression and co-repressor complex membership, knockout studies reveal distinct developmental functions. This work explores CtBP biology, emphasizing their dual roles, protein interactions, and implications for transcriptional regulation and tumorigenesis.
000000639 540__ $$fCC BY
000000639 542__ $$fIn copyright - single owner
000000639 650__ $$aDimerization$$031499
000000639 650__ $$aEmbryonic Development$$035917
000000639 650__ $$aEmbryology$$018342
000000639 650__ $$aDNA-Binding Proteins$$017998
000000639 650__ $$aCarcinogenesis$$040251
000000639 650__ $$aCo-Repressor Proteins$$038789
000000639 691__ $$aSchool of Medicine$$041369
000000639 692__ $$aDepartment of Biochemistry and Molecular Biology$$041396
000000639 7001_ $$aCurtis, Damian$$uOregon Health and Science University$$041354
000000639 7201_ $$aLundblad, James$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000639 8564_ $$9d01a1262-46a4-4363-9056-01b505dbf2d6$$s2662091$$uhttps://digitalcollections.ohsu.edu/record/639/files/640_etd.pdf$$ePublic$$2ede006ef486ad9235118d5342c788044$$31
000000639 905__ $$a/rest/prod/xg/94/hp/57/xg94hp577
000000639 909CO $$ooai:digitalcollections.ohsu.edu:639$$pstudent-work
000000639 980__ $$aTheses and Dissertations