000000642 001__ 642
000000642 005__ 20260120144837.0
000000642 0247_ $$2DOI$$a10.6083/M4X06510
000000642 037__ $$aETD
000000642 245__ $$aInvestigating manganese oxidation by Aurantimonas manganoxydans S185-9A1
000000642 260__ $$bOregon Health and Science University
000000642 269__ $$a2011
000000642 336__ $$aThesis
000000642 502__ $$bM.S.
000000642 520__ $$aManganese oxidation plays a key role in global biogeochemical cycling, yet its cellular function and enzymatic mechanisms remain unclear. This study identifies MopA, a novel Mn(II)-oxidizing peroxidase in Aurantimonas manganoxydans SI85-9A1—the first bacterial peroxidase linked to Mn oxidation. Functional assays suggest involvement of heme peroxidase and reactive oxygen species, with superoxide mediating Mn(II→III) and hydrogen peroxide Mn(III→IV) oxidation. Development of a genetic system via plasmid incorporation marks a breakthrough for mechanistic studies. Findings indicate Mn oxidation involves multiple oxygen-dependent steps and a complex protein system, advancing understanding of microbial manganese metabolism.
000000642 540__ $$fCC BY
000000642 542__ $$fIn copyright - single owner
000000642 650__ $$aManganese$$021806
000000642 650__ $$aPeroxidases$$023855
000000642 650__ $$aReactive Oxygen Species$$029926
000000642 650__ $$aPeroxidase$$022594
000000642 650__ $$aOxidation-Reduction$$023418
000000642 650__ $$aAurantimonas manganoxydans
000000642 6531_ $$aoxidation-reduction reaction
000000642 691__ $$aSchool of Medicine$$041369
000000642 692__ $$aDepartment of Environmental and Biomolecular Systems$$041414
000000642 7001_ $$aCaputo, Nicholas$$uOregon Health and Science University$$041354
000000642 7201_ $$aTebo, Bradley$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000642 7201_ $$aAnderson, Craig$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000642 8564_ $$90b5b3a6f-60f6-4a6d-8a71-274d0d31852a$$s1504353$$uhttps://digitalcollections.ohsu.edu/record/642/files/643_etd.pdf$$ePublic$$2a639a6bf4055695a33c05fc4ec25a194$$31
000000642 905__ $$a/rest/prod/cz/30/ps/67/cz30ps676
000000642 909CO $$ooai:digitalcollections.ohsu.edu:642$$pstudent-work
000000642 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000642 980__ $$aTheses and Dissertations