TY  - GEN
AB  - The cochlear nuclei are the first brain centers for auditory processing, where synaptic inhibition shapes neural output. Using patch-clamp recordings in avian and mammalian brainstem slices, this study examined inhibitory mechanisms. In chicks, inhibitory currents varied across nuclei specialized for timing or intensity processing, with glycine and GABA receptors contributing differentially. In mammals, glycinergic vertical cells exhibited fast-spiking properties but weak individual influence on principal neurons, requiring coordinated activity. Cartwheel cells, by contrast, fired spontaneously, and noradrenaline enhanced stimulus-evoked inhibition by suppressing spontaneous firing. These findings reveal diverse inhibitory strategies for auditory signal processing.
AD  - Oregon Health and Science University
AU  - Kuo, Sidney
DA  - 2011
DO  - 10.6083/M4NG4NM0
DO  - DOI
ED  - Trussell, Laurence
ED  - Advisor
ID  - 644
KW  - gamma-Aminobutyric Acid
KW  - Neurons
KW  - Electrophysiology
KW  - Synapses
KW  - Glycine
KW  - Cochlear Nucleus
KW  - Receptors, GABA
KW  - Auditory Perception
L1  - https://digitalcollections.ohsu.edu/record/644/files/645_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/644/files/645_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/644/files/645_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/644/files/645_etd.pdf
N2  - The cochlear nuclei are the first brain centers for auditory processing, where synaptic inhibition shapes neural output. Using patch-clamp recordings in avian and mammalian brainstem slices, this study examined inhibitory mechanisms. In chicks, inhibitory currents varied across nuclei specialized for timing or intensity processing, with glycine and GABA receptors contributing differentially. In mammals, glycinergic vertical cells exhibited fast-spiking properties but weak individual influence on principal neurons, requiring coordinated activity. Cartwheel cells, by contrast, fired spontaneously, and noradrenaline enhanced stimulus-evoked inhibition by suppressing spontaneous firing. These findings reveal diverse inhibitory strategies for auditory signal processing.
PB  - Oregon Health and Science University
PY  - 2011
T1  - Inhibitory synaptic transmission in early auditory processing
TI  - Inhibitory synaptic transmission in early auditory processing
UR  - https://digitalcollections.ohsu.edu/record/644/files/645_etd.pdf
Y1  - 2011
ER  -