000000644 001__ 644
000000644 005__ 20260120144837.0
000000644 0247_ $$2DOI$$a10.6083/M4NG4NM0
000000644 037__ $$aETD
000000644 245__ $$aInhibitory synaptic transmission in early auditory processing
000000644 260__ $$bOregon Health and Science University
000000644 269__ $$a2011
000000644 336__ $$aDissertation
000000644 502__ $$bPh.D.
000000644 502__ $$gNeuroscience
000000644 520__ $$aThe cochlear nuclei are the first brain centers for auditory processing, where synaptic inhibition shapes neural output. Using patch-clamp recordings in avian and mammalian brainstem slices, this study examined inhibitory mechanisms. In chicks, inhibitory currents varied across nuclei specialized for timing or intensity processing, with glycine and GABA receptors contributing differentially. In mammals, glycinergic vertical cells exhibited fast-spiking properties but weak individual influence on principal neurons, requiring coordinated activity. Cartwheel cells, by contrast, fired spontaneously, and noradrenaline enhanced stimulus-evoked inhibition by suppressing spontaneous firing. These findings reveal diverse inhibitory strategies for auditory signal processing.
000000644 540__ $$fCC BY
000000644 542__ $$fIn copyright - single owner
000000644 650__ $$agamma-Aminobutyric Acid$$019337
000000644 650__ $$aNeurons$$022858
000000644 650__ $$aElectrophysiology$$018311
000000644 650__ $$aSynapses$$026704
000000644 650__ $$aGlycine$$019632
000000644 650__ $$aCochlear Nucleus$$030119
000000644 650__ $$aReceptors, GABA$$030487
000000644 650__ $$aAuditory Perception$$015222
000000644 691__ $$aSchool of Medicine$$041369
000000644 692__ $$aVollum Institute$$041509
000000644 7001_ $$aKuo, Sidney$$uOregon Health and Science University$$041354
000000644 7201_ $$aTrussell, Laurence$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000644 8564_ $$93bcf9f22-91ef-4867-a537-0bc750607fb8$$s3249219$$uhttps://digitalcollections.ohsu.edu/record/644/files/645_etd.pdf$$ePublic$$2c41f94e9626d40923c0f5255f2d06073$$31
000000644 905__ $$a/rest/prod/9p/29/09/37/9p290937n
000000644 909CO $$ooai:digitalcollections.ohsu.edu:644$$pstudent-work
000000644 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000644 980__ $$aTheses and Dissertations