000000645 001__ 645
000000645 005__ 20260219122743.0
000000645 0247_ $$2DOI$$a10.6083/M4HT2M90
000000645 037__ $$aETD
000000645 245__ $$aInference of physiologic processes using otoacoustic emissions
000000645 260__ $$bOregon Health and Science University
000000645 269__ $$a2010
000000645 336__ $$aDissertation
000000645 502__ $$bPh.D.
000000645 520__ $$aThis dissertation develops noninvasive methods for inferring physiologic processes using features of otoacoustic emissions (OAEs). Studies demonstrate that stimulus‑frequency OAEs and medial olivocochlear (MOC)–related changes correlate with blood glucose levels, leading to a proposed mechanism linking glucose‑dependent cochlear metabolism to OAE behavior. A new prediction method, Hyperglycemic Risk Analysis, achieved strong accuracy for detecting elevated glucose. Additional experiments show that focused auditory attention increases MOC inhibition, and age‑related changes in SF OAE amplitude and latency can predict auditory decline. Together, these findings expand the clinical and diagnostic potential of OAE‑based physiologic monitoring.
000000645 540__ $$fCC BY
000000645 542__ $$fIn copyright - single owner
000000645 650__ $$aAging$$014358
000000645 650__ $$aBlood Glucose$$015661
000000645 650__ $$aEfferent Pathways$$018246
000000645 650__ $$aROC Curve$$025585
000000645 650__ $$aPsychoacoustics$$024824
000000645 650__ $$aHair Cells, Auditory, Outer$$030480
000000645 650__ $$aHearing$$019916
000000645 650__ $$aAcoustics$$014161
000000645 650__ $$aBlood Glucose Self-Monitoring$$028204
000000645 6531_ $$aotoacoustic emissions
000000645 6531_ $$amedial olivocochlear
000000645 6531_ $$aacoustic emission
000000645 6531_ $$aauditory attention
000000645 691__ $$aSchool of Medicine$$041369
000000645 692__ $$aDepartment of Biomedical Engineering$$041397
000000645 7001_ $$aGordon Jacobs, Peter$$uOregon Health and Science University$$041354
000000645 7201_ $$aWan, Eric$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000645 8564_ $$90155b419-96f6-4ba7-a014-33acc58d79c6$$s2423576$$uhttps://digitalcollections.ohsu.edu/record/645/files/646_etd.pdf$$ePublic$$2f27a1842bb93372234cb15c0268b3418$$31
000000645 905__ $$a/rest/prod/z0/29/p4/76/z029p4761
000000645 909CO $$ooai:digitalcollections.ohsu.edu:645$$pstudent-work
000000645 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000645 980__ $$aTheses and Dissertations