@article{ETD,
      recid = {652},
      author = {Johnsen, Dustin},
      title = {Cellular mechanisms of neurodegeneration and  neuroprotection in the mammalian cortex},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2011},
      number = {ETD},
      abstract = {Neurodegeneration, a leading cause of morbidity and  mortality, results from progressive CNS dysfunction and  cell death. This dissertation investigates neuroprotective  and neurodegenerative mechanisms using two approaches.  First, studies in sex-segregated neurons and astrocytes  examined isoflurane preconditioning and 17β-estradiol  effects on survival following oxygen-glucose deprivation,  revealing sex-independent protection by isoflurane and  estradiol-mediated modulation in female neurons. Second,  experiments assessed cyclophilin D’s role in cell death,  showing its involvement in oxidant-induced injury but not  excitotoxic or energetic stress. Findings highlight  sex-specific neuroprotective responses and identify  cyclophilin D as a mediator of oxidative damage, informing  strategies to mitigate neurodegeneration.},
      url = {http://digitalcollections.ohsu.edu/record/652},
      doi = {https://doi.org/10.6083/M4MK69WX},
}