TY  - GEN
AB  - Neurodegeneration, a leading cause of morbidity and mortality, results from progressive CNS dysfunction and cell death. This dissertation investigates neuroprotective and neurodegenerative mechanisms using two approaches. First, studies in sex-segregated neurons and astrocytes examined isoflurane preconditioning and 17β-estradiol effects on survival following oxygen-glucose deprivation, revealing sex-independent protection by isoflurane and estradiol-mediated modulation in female neurons. Second, experiments assessed cyclophilin D’s role in cell death, showing its involvement in oxidant-induced injury but not excitotoxic or energetic stress. Findings highlight sex-specific neuroprotective responses and identify cyclophilin D as a mediator of oxidative damage, informing strategies to mitigate neurodegeneration.
AD  - Oregon Health and Science University
AU  - Johnsen, Dustin
DA  - 2011
DO  - 10.6083/M4MK69WX
DO  - DOI
ED  - Murphy, Stephanie
ED  - Advisor
ID  - 652
KW  - Astrocytes
KW  - Neurodegenerative Diseases
KW  - Cyclophilins
KW  - Peptidylprolyl Isomerase
KW  - Nervous System
KW  - Isoflurane
KW  - Sex Characteristics
KW  - sex differences
L1  - https://digitalcollections.ohsu.edu/record/652/files/653_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/652/files/653_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/652/files/653_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/652/files/653_etd.pdf
N2  - Neurodegeneration, a leading cause of morbidity and mortality, results from progressive CNS dysfunction and cell death. This dissertation investigates neuroprotective and neurodegenerative mechanisms using two approaches. First, studies in sex-segregated neurons and astrocytes examined isoflurane preconditioning and 17β-estradiol effects on survival following oxygen-glucose deprivation, revealing sex-independent protection by isoflurane and estradiol-mediated modulation in female neurons. Second, experiments assessed cyclophilin D’s role in cell death, showing its involvement in oxidant-induced injury but not excitotoxic or energetic stress. Findings highlight sex-specific neuroprotective responses and identify cyclophilin D as a mediator of oxidative damage, informing strategies to mitigate neurodegeneration.
PB  - Oregon Health and Science University
PY  - 2011
T1  - Cellular mechanisms of neurodegeneration and neuroprotection in the mammalian cortex
TI  - Cellular mechanisms of neurodegeneration and neuroprotection in the mammalian cortex
UR  - https://digitalcollections.ohsu.edu/record/652/files/653_etd.pdf
Y1  - 2011
ER  -