000000652 001__ 652
000000652 005__ 20260107130131.0
000000652 0247_ $$2DOI$$a10.6083/M4MK69WX
000000652 037__ $$aETD
000000652 245__ $$aCellular mechanisms of neurodegeneration and neuroprotection in the mammalian cortex
000000652 260__ $$bOregon Health and Science University
000000652 269__ $$a2011
000000652 336__ $$aDissertation
000000652 502__ $$bPh.D.
000000652 502__ $$gNeuroscience
000000652 520__ $$aNeurodegeneration, a leading cause of morbidity and mortality, results from progressive CNS dysfunction and cell death. This dissertation investigates neuroprotective and neurodegenerative mechanisms using two approaches. First, studies in sex-segregated neurons and astrocytes examined isoflurane preconditioning and 17β-estradiol effects on survival following oxygen-glucose deprivation, revealing sex-independent protection by isoflurane and estradiol-mediated modulation in female neurons. Second, experiments assessed cyclophilin D’s role in cell death, showing its involvement in oxidant-induced injury but not excitotoxic or energetic stress. Findings highlight sex-specific neuroprotective responses and identify cyclophilin D as a mediator of oxidative damage, informing strategies to mitigate neurodegeneration.
000000652 540__ $$fCC BY
000000652 542__ $$fIn copyright - single owner
000000652 650__ $$aAstrocytes$$015172
000000652 650__ $$aNeurodegenerative Diseases$$031750
000000652 650__ $$aCyclophilins$$032917
000000652 650__ $$aPeptidylprolyl Isomerase$$031803
000000652 650__ $$aNervous System$$022807
000000652 650__ $$aIsoflurane$$021065
000000652 650__ $$aSex Characteristics$$025917
000000652 6531_ $$asex differences
000000652 691__ $$aSchool of Medicine$$041369
000000652 692__ $$aVollum Institute$$041509
000000652 7001_ $$aJohnsen, Dustin$$uOregon Health and Science University$$041354
000000652 7201_ $$aMurphy, Stephanie$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000652 8564_ $$9a334e7c9-f7f0-4f0b-87c5-5b42106716f9$$s2614666$$uhttps://digitalcollections.ohsu.edu/record/652/files/653_etd.pdf$$ePublic$$260005bea43972d82b88258605bccd514$$31
000000652 905__ $$a/rest/prod/g1/58/bh/31/g158bh310
000000652 909CO $$ooai:digitalcollections.ohsu.edu:652$$pstudent-work
000000652 980__ $$aTheses and Dissertations