@article{ETD,
      recid = {653},
      author = {Kelley, Melissa},
      title = {The effect of ischemia on cerebellar purkinje cell GABAA  receptors},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2011},
      number = {ETD},
      abstract = {Purkinje cells (PCs) are highly vulnerable to ischemic  injury, yet the role of GABAergic signaling in cerebellar  neuroprotection remains poorly defined. Using cerebellar  cultures subjected to oxygen‑glucose deprivation and a  mouse model of global ischemia, we found that ischemia  rapidly reduces GABAA_AA​ receptor currents and protein  levels in PCs while sparing β1‑containing receptors. The  neurosteroid allopregnanolone (ALLO) prevented this  ischemia‑induced decline and protected PCs both in vitro  and in vivo. ALLO’s protective effects were more pronounced  in females at low doses. These findings identify GABAA_AA​  receptor loss as a key contributor to PC vulnerability and  highlight ALLO as a promising therapeutic candidate for  ischemic cerebellar injury.},
      url = {http://digitalcollections.ohsu.edu/record/653},
      doi = {https://doi.org/10.6083/M4GT5K62},
}