000000654 001__ 654
000000654 005__ 20260130124216.0
000000654 0247_ $$2DOI$$a10.6083/M4C24TF6
000000654 037__ $$aETD
000000654 245__ $$aThe individual and unique roles for eosinophils and interleukin-5 in the innate immune response to sepsis
000000654 260__ $$bOregon Health and Science University
000000654 269__ $$a2011
000000654 336__ $$aDissertation
000000654 502__ $$bPh.D.
000000654 502__ $$gMolecular Microbiology & Immunology (sunsetting)
000000654 520__ $$aSepsis is a life‑threatening inflammatory response to infection and remains a major clinical challenge. Although sepsis causes widespread immune dysfunction and eosinopenia, recent evidence links higher IL‑5 levels with improved patient survival. This work clarifies the roles of eosinophils and IL‑5 in sepsis. Eosinophils show direct antibacterial activity through granule‑mediated killing, improving bacterial clearance in vivo. IL‑5 also provides protection independent of eosinophils, enhancing survival, promoting neutrophil recruitment, and activating macrophages through increased cytokine production, phagocytosis, and STAT‑1 signaling. These findings reveal IL‑5 and eosinophil granules as potential therapeutic strategies and suggest caution when using anti‑IL‑5–based treatments in septic patients.
000000654 540__ $$fCC BY
000000654 542__ $$fIn copyright - single owner
000000654 650__ $$aImmunity, Innate$$020672
000000654 650__ $$aInterleukins$$020920
000000654 650__ $$aSepsis$$031109
000000654 650__ $$aNeutrophils$$022885
000000654 650__ $$aInterleukin-5$$028701
000000654 650__ $$aMacrophages$$021733
000000654 650__ $$aEosinophils$$018511
000000654 6531_ $$anatural immunity
000000654 6531_ $$asepticemia
000000654 691__ $$aSchool of Medicine$$041369
000000654 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000654 7001_ $$aLinch, Stefanie$$uOregon Health and Science University$$041354
000000654 7201_ $$aGold, Jeffrey$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000654 8564_ $$9996e51c9-a2b5-4fb0-95ee-6888a4f6ea27$$s4127320$$uhttps://digitalcollections.ohsu.edu/record/654/files/655_etd.pdf$$ePublic$$2f69c7f3bb5cfa2f917f5336c95bd06b0$$31
000000654 905__ $$a/rest/prod/wh/24/6s/21/wh246s217
000000654 909CO $$ooai:digitalcollections.ohsu.edu:654$$pstudent-work
000000654 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000654 980__ $$aTheses and Dissertations