000000656 001__ 656
000000656 005__ 20260203142954.0
000000656 0247_ $$2DOI$$a10.6083/M43J39ZP
000000656 037__ $$aETD
000000656 245__ $$aBDNF in developing aortic baroreceptors & its role in the dendritic morphogenesis of neurons from the nucleus tractus solitarius
000000656 260__ $$bOregon Health and Science University
000000656 269__ $$a2010
000000656 336__ $$aDissertation
000000656 502__ $$bPh.D.
000000656 502__ $$gNeuroscience
000000656 520__ $$aCardiorespiratory reflexes, which regulate breathing and blood pressure, differ markedly between newborns and adults, suggesting significant postnatal maturation of their neural circuits. The mechanisms that guide this maturation remain largely unknown but are critical for understanding developmental disorders such as Sudden Infant Death Syndrome. This work tests the hypothesis that brain‑derived neurotrophic factor (BDNF) released from cardiorespiratory afferents drives activity‑dependent development in the nucleus tractus solitarius (NTS). I show that BDNF is present and released from baroreceptor neurons in patterns mimicking physiological activity and that BDNF influences dendritic growth of NTS neurons. These effects depend strongly on glial interactions, revealing an essential but underappreciated role for glia in shaping dendritogenesis. Together, these findings identify BDNF‑glia interactions as key contributors to maturation of cardiorespiratory pathways.
000000656 540__ $$fCC BY
000000656 542__ $$fIn copyright - single owner
000000656 650__ $$aAstrocytes$$015172
000000656 650__ $$aPressoreceptors$$024581
000000656 650__ $$aCell Culture Techniques$$031208
000000656 650__ $$aDendrites$$017467
000000656 650__ $$aNeuroglia$$022841
000000656 650__ $$aBrain-Derived Neurotrophic Factor$$031432
000000656 650__ $$aSolitary Nucleus$$030060
000000656 6531_ $$abaroreceptors
000000656 691__ $$aSchool of Medicine$$041369
000000656 692__ $$aVollum Institute$$041509
000000656 7001_ $$aMartin, Jessica$$uOregon Health and Science University$$041354
000000656 8564_ $$92faf59a6-e107-45ae-bcbc-f39e2a5c1679$$s2881956$$uhttps://digitalcollections.ohsu.edu/record/656/files/657_etd.pdf$$ePublic$$2872032717acb170a4adf90c6ebc8db00$$31
000000656 905__ $$a/rest/prod/n8/70/zq/89/n870zq89h
000000656 909CO $$ooai:digitalcollections.ohsu.edu:656$$pstudent-work
000000656 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000656 980__ $$aTheses and Dissertations