000000657 001__ 657
000000657 005__ 20260112082933.0
000000657 0247_ $$2DOI$$a10.6083/M4ZS2TGD
000000657 037__ $$aETD
000000657 245__ $$aExtinction of ethanol-seeking behavior: the role of extracellular signal-regulated kinase signaling and medial prefrontal cortex circuitry in extinction of ethanol-induced conditioned place preference in mice
000000657 260__ $$bOregon Health and Science University
000000657 269__ $$a2011
000000657 336__ $$aDissertation
000000657 502__ $$bPh.D.
000000657 502__ $$gBehavioral & Systems Neuroscience
000000657 520__ $$aExtinction of ethanol-induced conditioned place preference (EtOH-CPP) remains poorly understood compared to acquisition and expression phases. This study systematically examined the neurochemistry and neurocircuitry underlying EtOH-CPP extinction in mice. Manipulations of ERK signaling using D-cycloserine (DCS) or SL327 did not impair extinction, suggesting ERK pathways are not critical for this process. In contrast, immunohistochemistry and electrolytic lesion experiments indicated that the medial prefrontal cortex (mPFC) is essential for extinction. Attempts to employ extinction-specific intra-mPFC microinjections were inconclusive due to incomplete extinction in controls. These findings provide the first comprehensive evidence implicating mPFC involvement in EtOH-CPP extinction, while ERK signaling appears non-essential.
000000657 540__ $$fCC BY
000000657 542__ $$fIn copyright - single owner
000000657 650__ $$aMitogen-Activated Protein Kinases$$032817
000000657 650__ $$aMitogen-Activated Protein Kinase 10$$036042
000000657 650__ $$aPrefrontal Cortex$$029938
000000657 650__ $$aEthanol$$014406
000000657 650__ $$aExtinction, Psychological$$018795
000000657 650__ $$aMice$$036842
000000657 650__ $$aPrefrontal Cortex$$029938
000000657 650__ $$aExtracellular Signal-Regulated MAP Kinases$$036035
000000657 6531_ $$aconditioned place preference
000000657 691__ $$aSchool of Medicine$$041369
000000657 692__ $$aDepartment of Behavioral Neuroscience$$041394
000000657 7001_ $$aGroblewski, Peter$$uOregon Health and Science University$$041354
000000657 7201_ $$aCunningham, Christopher$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000657 8564_ $$9e45c0221-017e-4813-b612-a5d23f16e3c2$$s2723121$$uhttps://digitalcollections.ohsu.edu/record/657/files/658_etd.pdf$$ePublic$$20efbfd9e582b5304039a127af3d35d6a$$31
000000657 905__ $$a/rest/prod/b5/64/4r/55/b5644r55p
000000657 909CO $$ooai:digitalcollections.ohsu.edu:657$$pstudent-work
000000657 980__ $$aTheses and Dissertations