000000660 001__ 660
000000660 005__ 20260220130727.0
000000660 0247_ $$2DOI$$a10.6083/M4KK98S0
000000660 037__ $$aETD
000000660 245__ $$aProinflammatory responses triggerd by ricin toxin require macrophages and IL-1β signaling through the NALP3 inflammasome
000000660 260__ $$bOregon Health and Science University
000000660 269__ $$a2010
000000660 336__ $$aDissertation
000000660 502__ $$bPh.D.
000000660 520__ $$aRicin is a ribotoxic stressor that blocks protein synthesis and activates stress‑activated protein kinases, but its mechanisms of inducing inflammation remain unclear. Because aerosolized ricin poses a significant bioterrorism risk, understanding its pulmonary effects is critical. This dissertation investigates ricin‑triggered inflammatory responses in the lungs of mice. The findings show that ricin exposure induces strong expression of inflammatory genes, edema, increased microvascular permeability, and pronounced neutrophil infiltration. These results identify key features of ricin‑mediated lung injury and help clarify the molecular basis of ricin‑induced inflammation.
000000660 540__ $$fCC BY
000000660 542__ $$fIn copyright - single owner
000000660 650__ $$aCarrier Proteins$$016184
000000660 650__ $$aInflammation$$020800
000000660 650__ $$aMacrophages$$021733
000000660 650__ $$aLung$$021644
000000660 650__ $$aInterleukin-1$$020917
000000660 650__ $$aRicin$$025496
000000660 6531_ $$alungs
000000660 691__ $$aSchool of Medicine$$041369
000000660 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000000660 7001_ $$aLindauer, Meghan$$uOregon Health and Science University$$041354
000000660 7201_ $$aMagun, Bruce$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000660 8564_ $$91369f644-01b7-4444-b473-6b4b5ba837f6$$s7338855$$uhttps://digitalcollections.ohsu.edu/record/660/files/661_etd.pdf$$ePublic$$2c0cd70df0f1ba837a3c9b4c660b21ada$$31
000000660 905__ $$a/rest/prod/r4/94/vk/21/r494vk213
000000660 909CO $$ooai:digitalcollections.ohsu.edu:660$$pstudent-work
000000660 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000660 980__ $$aTheses and Dissertations