000000662 001__ 662
000000662 005__ 20260225152954.0
000000662 0247_ $$2DOI$$a10.6083/M4B27S8C
000000662 037__ $$aETD
000000662 245__ $$aThe role of B cell subset in peripheral T cell tolerance induction
000000662 260__ $$bOregon Health and Science University
000000662 269__ $$a2010
000000662 336__ $$aThesis
000000662 502__ $$bM.S.
000000662 520__ $$aCentral tolerance removes many self‑reactive lymphocytes during development, yet some autoreactive cells escape to the periphery, requiring additional mechanisms to prevent autoimmunity. Transitional B cells encountering self‑antigen typically undergo anergy and apoptosis, while mature T cells may become anergic, apoptotic, or differentiate into regulatory T cells. This study investigates the contribution of transitional and mature B cell subsets to peripheral T cell tolerance. Using an in vivo model, we show that both transitional and mature follicular B cells can induce antigen‑specific T cell anergy. In vitro studies further assess their ability to convert naïve T cells into regulatory T cells. Together, these findings support a role for specific B cell subsets in promoting peripheral T cell tolerance.
000000662 540__ $$fCC BY
000000662 542__ $$fIn copyright - single owner
000000662 650__ $$aT-Lymphocytes$$026731
000000662 650__ $$aAutoimmunity$$028491
000000662 650__ $$aB-Lymphocyte Subsets$$028936
000000662 650__ $$aPeripheral Tolerance$$039875
000000662 650__ $$aBone Marrow$$015725
000000662 650__ $$aCentral Tolerance$$039876
000000662 650__ $$at cells
000000662 650__ $$aPrecursor Cells, B-Lymphoid$$037853
000000662 650__ $$aT-Lymphocytes, Regulatory$$036362
000000662 650__ $$aImmunity$$020668
000000662 691__ $$aSchool of Medicine$$041369
000000662 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000662 7001_ $$aMartin, Erin$$uOregon Health and Science University$$041354
000000662 7201_ $$aParker, David$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000662 8564_ $$99e86e27d-31f5-4fea-8ce6-ca5ded9d2f7b$$s1183006$$uhttps://digitalcollections.ohsu.edu/record/662/files/663_etd.pdf$$ePublic$$2c6a924723c67a30c8585e8411d7fe4ec$$31
000000662 905__ $$a/rest/prod/9g/54/xh/68/9g54xh68r
000000662 909CO $$ooai:digitalcollections.ohsu.edu:662$$pstudent-work
000000662 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000662 980__ $$aTheses and Dissertations