@article{ETD,
      recid = {671},
      author = {Tibbitts, Deanne},
      title = {Characterization of aberrant c-Myc phosphorylation and  stability in acute myeloid and lymphoblastic leukemia},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2011},
      number = {ETD},
      abstract = {c-Myc is a key transcription factor regulating  hematopoiesis, and its overexpression is common in  leukemia. c-Myc stability is controlled by phosphorylation  at serine 62 (S62) and threonine 58 (T58), influencing  protein degradation. This dissertation demonstrates that  elevated c-Myc levels in lymphoid and myeloid leukemia are  linked to increased protein stability and altered  phosphorylation at these sites. Mechanisms include  constitutive activation of upstream signaling and  deregulation of degradation-promoting proteins.  Overexpression of AXIN1 in a mouse lymphoma model delayed  tumor onset, supporting strategies to target c-Myc  stability. These findings identify aberrant c-Myc  stabilization as a therapeutic target in leukemia.},
      url = {http://digitalcollections.ohsu.edu/record/671},
      doi = {https://doi.org/10.6083/M45B00FN},
}