000000671 001__ 671
000000671 005__ 20260107160202.0
000000671 0247_ $$2DOI$$a10.6083/M45B00FN
000000671 037__ $$aETD
000000671 245__ $$aCharacterization of aberrant c-Myc phosphorylation and stability in acute myeloid and lymphoblastic leukemia
000000671 260__ $$bOregon Health and Science University
000000671 269__ $$a2011
000000671 336__ $$aDissertation
000000671 502__ $$bPh.D.
000000671 502__ $$gMolecular & Medical Genetics (sunsetting)
000000671 520__ $$ac-Myc is a key transcription factor regulating hematopoiesis, and its overexpression is common in leukemia. c-Myc stability is controlled by phosphorylation at serine 62 (S62) and threonine 58 (T58), influencing protein degradation. This dissertation demonstrates that elevated c-Myc levels in lymphoid and myeloid leukemia are linked to increased protein stability and altered phosphorylation at these sites. Mechanisms include constitutive activation of upstream signaling and deregulation of degradation-promoting proteins. Overexpression of AXIN1 in a mouse lymphoma model delayed tumor onset, supporting strategies to target c-Myc stability. These findings identify aberrant c-Myc stabilization as a therapeutic target in leukemia.
000000671 540__ $$fCC BY
000000671 542__ $$fIn copyright - single owner
000000671 650__ $$aPrecursor Cell Lymphoblastic Leukemia-Lymphoma$$037720
000000671 650__ $$aProto-Oncogene Proteins c-myc$$029021
000000671 650__ $$aPhosphorylation$$024067
000000671 650__ $$aLeukemia$$021430
000000671 650__ $$aProtein Stability$$038363
000000671 650__ $$aLeukemia, Myeloid, Acute$$028432
000000671 650__ $$aAxin Protein$$039753
000000671 6531_ $$alymphoblastic leukemia
000000671 6531_ $$amyc proteins
000000671 691__ $$aSchool of Medicine$$041369
000000671 692__ $$aDepartment of Molecular and Medical Genetics$$041428
000000671 7001_ $$aTibbitts, Deanne$$uOregon Health and Science University$$041354
000000671 7201_ $$aSears, Rosalie$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000671 7201_ $$aStork, Phillip$$uOregon Health and Science University$$041354$$7Personal$$eChair
000000671 8564_ $$923672dc2-6a5e-429f-81ac-3c75c9aed905$$s3422156$$uhttps://digitalcollections.ohsu.edu/record/671/files/672_etd.pdf$$ePublic$$2e55d02cb57e5d443ef67ac33d35918f1$$31
000000671 905__ $$a/rest/prod/f1/88/1k/95/f1881k95p
000000671 909CO $$ooai:digitalcollections.ohsu.edu:671$$pstudent-work
000000671 980__ $$aTheses and Dissertations