TY  - GEN
AB  - Periventricular white matter injury (WMI) is a major cause of cerebral palsy in preterm infants, yet mechanisms remain unclear. Using a fetal sheep ischemia-reperfusion model, we combined cerebral blood flow mapping, histopathology, and high-field MRI to study WMI evolution. Injury localized to regions enriched in late oligodendrocyte progenitors (preOLs), which degenerated acutely but later proliferated without maturing, leading to gliotic lesions. MRI identified four lesion types, including two novel T2 hypo-intense signals correlating with necrosis or gliosis. Axonal structure remained intact in diffuse gliosis. Findings suggest ischemia triggers WMI via preOL vulnerability and maturation arrest, highlighting MRI’s potential for early detection.
AD  - Oregon Health and Science University
AU  - Riddle, Art
DA  - 2011
DO  - 10.6083/M41J97RT
DO  - DOI
ID  - 672
KW  - Brain Injuries
KW  - Ischemia
KW  - Cerebral Palsy
KW  - Magnetic Resonance Imaging
KW  - White Matter
KW  - Infant
KW  - Infant Health
KW  - Infant, Premature
KW  - Brain Ischemia
KW  - brain damage
L1  - https://digitalcollections.ohsu.edu/record/672/files/673_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/672/files/673_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/672/files/673_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/672/files/673_etd.pdf
N2  - Periventricular white matter injury (WMI) is a major cause of cerebral palsy in preterm infants, yet mechanisms remain unclear. Using a fetal sheep ischemia-reperfusion model, we combined cerebral blood flow mapping, histopathology, and high-field MRI to study WMI evolution. Injury localized to regions enriched in late oligodendrocyte progenitors (preOLs), which degenerated acutely but later proliferated without maturing, leading to gliotic lesions. MRI identified four lesion types, including two novel T2 hypo-intense signals correlating with necrosis or gliosis. Axonal structure remained intact in diffuse gliosis. Findings suggest ischemia triggers WMI via preOL vulnerability and maturation arrest, highlighting MRI’s potential for early detection.
PB  - Oregon Health and Science University
PY  - 2011
T1  - Histopathological and MRI correlates of perinatal white matter injury
TI  - Histopathological and MRI correlates of perinatal white matter injury
UR  - https://digitalcollections.ohsu.edu/record/672/files/673_etd.pdf
Y1  - 2011
ER  -