000000672 001__ 672
000000672 005__ 20260112102817.0
000000672 0247_ $$2DOI$$a10.6083/M41J97RT
000000672 037__ $$aETD
000000672 245__ $$aHistopathological and MRI correlates of perinatal white matter injury
000000672 260__ $$bOregon Health and Science University
000000672 269__ $$a2011
000000672 336__ $$aDissertation
000000672 502__ $$bPh.D.
000000672 502__ $$gNeuroscience
000000672 520__ $$aPeriventricular white matter injury (WMI) is a major cause of cerebral palsy in preterm infants, yet mechanisms remain unclear. Using a fetal sheep ischemia-reperfusion model, we combined cerebral blood flow mapping, histopathology, and high-field MRI to study WMI evolution. Injury localized to regions enriched in late oligodendrocyte progenitors (preOLs), which degenerated acutely but later proliferated without maturing, leading to gliotic lesions. MRI identified four lesion types, including two novel T2 hypo-intense signals correlating with necrosis or gliosis. Axonal structure remained intact in diffuse gliosis. Findings suggest ischemia triggers WMI via preOL vulnerability and maturation arrest, highlighting MRI’s potential for early detection.
000000672 540__ $$fCC BY
000000672 542__ $$fIn copyright - single owner
000000672 650__ $$aBrain Injuries$$015797
000000672 650__ $$aIschemia$$021046
000000672 650__ $$aCerebral Palsy$$016369
000000672 650__ $$aMagnetic Resonance Imaging$$021747
000000672 650__ $$aWhite Matter$$040768
000000672 650__ $$aInfant$$020774
000000672 650__ $$aInfant Health$$011216
000000672 650__ $$aInfant, Premature$$020785
000000672 650__ $$aBrain Ischemia$$016367
000000672 6531_ $$abrain damage
000000672 691__ $$aSchool of Medicine$$041369
000000672 692__ $$aVollum Institute$$041509
000000672 692__ $$aDoernbecher Children's Hospital$$041469
000000672 7001_ $$aRiddle, Art$$uOregon Health and Science University$$041354
000000672 8564_ $$9a6f1fe9c-9efa-47e2-bb37-9c7c4483b6af$$s5093627$$uhttps://digitalcollections.ohsu.edu/record/672/files/673_etd.pdf$$ePublic$$248ab623c6b853e03a65b52b053e9293e$$31
000000672 905__ $$a/rest/prod/2b/88/qc/21/2b88qc21b
000000672 909CO $$ooai:digitalcollections.ohsu.edu:672$$pstudent-work
000000672 980__ $$aTheses and Dissertations