@article{ETD,
      recid = {679},
      author = {White, Ruth},
      title = {MicroRNA regulation of tumor-initiating-cells in  metastasis and chemoresistance},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2011},
      number = {ETD},
      abstract = {Tumor-initiating cells (TICs) drive tumor formation and  may contribute to metastasis. Using a mouse model of  squamous cell carcinoma (SCC), we identified two TIC  populations: Hoechst dye-excluding side population (SP) and  SP-/CD34+/CD49f+ cells. SP size correlated with lung  metastasis and increased in passaged tumors. miRNA  profiling revealed miR-9 upregulation in metastatic SP  cells, promoting chemoresistance and invasion via Abcb1a  regulation. In human HNSCC, miR-9 expression associated  with metastatic node status in passaged tumors. Sox2 was  elevated in SP-/CD34+/CD49f+ cells, inhibiting invasion,  suggesting distinct roles for TIC subsets. These findings  implicate miR-9 and Sox2 in TIC-driven metastasis.},
      url = {http://digitalcollections.ohsu.edu/record/679},
      doi = {https://doi.org/10.6083/M44F1NQ6},
}