000000683 001__ 683
000000683 005__ 20260120144837.0
000000683 0247_ $$2DOI$$a10.6083/M4MC8X1V
000000683 037__ $$aETD
000000683 245__ $$aAcute bronchodilator effects of toll-like receptor 7 agonists
000000683 260__ $$bOregon Health and Science University
000000683 269__ $$a2011
000000683 336__ $$aDissertation
000000683 502__ $$bPh.D.
000000683 502__ $$gPhysiology & Pharmacology (sunsetting)
000000683 520__ $$aRespiratory viral infections trigger asthma exacerbations, yet the acute effects of Toll-like receptor 7 (TLR7) signaling on airway physiology are poorly understood. This study shows that TLR7 agonists rapidly abolish airway smooth muscle contraction in guinea pigs, mice, and humans. Bronchodilation occurs via TLR7-dependent nitric oxide pathways and TLR7-independent mechanisms involving prostaglandins and potassium channels. Reduced efficacy in allergen-sensitized and virus-infected models suggests a link to asthma severity and TLR7 polymorphisms. Despite diminished potency, TLR7 agonists retain bronchodilatory activity, indicating potential as a combined prophylactic and rescue therapy for asthma, offering a novel approach to reduce medication burden and side effects.
000000683 540__ $$fCC BY
000000683 542__ $$fIn copyright - single owner
000000683 650__ $$aRespiratory Tract Infections$$025370
000000683 650__ $$aNitric Oxide$$022931
000000683 650__ $$aToll-Like Receptor 7$$036757
000000683 650__ $$aRespiratory Physiological Phenomena$$025372
000000683 650__ $$aAsthma$$015168
000000683 650__ $$aVirus Diseases$$027847
000000683 650__ $$aMice$$036842
000000683 650__ $$aGuinea Pigs$$019785
000000683 650__ $$aMuscle Contraction$$022522
000000683 650__ $$aMuscle, Smooth$$022533
000000683 6531_ $$abronchodilation
000000683 6531_ $$atlr7
000000683 691__ $$aSchool of Medicine$$041369
000000683 692__ $$aDepartment of Physiology and Pharmacology$$041442
000000683 7001_ $$aKaufman, Elad$$uOregon Health and Science University$$041354
000000683 7201_ $$aJacoby, David$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000683 8564_ $$9a7300e66-a9b0-47cb-b559-63d78a830ab3$$s1993995$$uhttps://digitalcollections.ohsu.edu/record/683/files/684_etd.pdf$$ePublic$$2512cab75c636ef8c47351108e81519e7$$31
000000683 905__ $$a/rest/prod/xd/07/gs/74/xd07gs74p
000000683 909CO $$ooai:digitalcollections.ohsu.edu:683$$pstudent-work
000000683 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000683 980__ $$aTheses and Dissertations